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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Scheen, André J. |
| Description | Country affiliation: Belgium Author Affiliation: Scheen AJ ( University of Liège, Division of Diabetes, Nutrition and Metabolic Disorders, Department of Medicine, CHU Sart-Tilman (B35), B-4000 Liège 1, Belgium. andre.scheen@chu.ulg.ac.be) |
| Abstract | INTRODUCTION: Metformin is the first-choice drug in the management of type 2 diabetes. However, most patients require a combined therapy to reach and/or maintain targets of glucose control. Dipeptidyl peptidase-4 (DPP-4) inhibitors offer new options for combined therapy with metformin. Linagliptin shares a similar pharmacodynamic (PD) profile with other gliptins, but has a unique pharmacokinetic (PK) profile characterized by negligible renal excretion. AREAS COVERED: An extensive literature search was performed to analyze the potential PK/PD interactions between linagliptin and metformin. They are not prone to PK drug-drug interactions. The two compounds may be administered together, either separately or using a fixed-dose combination (FDC) as shown by bioequivalence studies. The addition of linagliptin in patients not well controlled with metformin alone has proven its efficacy in improving glucose levels with a good safety profile. Initial co-administration of linagliptin plus metformin improves glucose control more potently than either compound separately, without hypoglycemia, weight gain or increased metformin-related gastrointestinal side effects. EXPERT OPINION: The linagliptin plus metformin combination may offer some advantages over the classical sulfonylurea-metformin combination. Even if linagliptin is safe in patients with renal impairment, the use of metformin (and thus of the linagliptin plus metformin FDC) is still controversial in this population. |
| File Format | HTM / HTML |
| ISSN | 14740338 |
| Issue Number | 2 |
| Volume Number | 12 |
| e-ISSN | 1744764X |
| Journal | Expert Opinion on Drug Safety |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2013-03-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Diabetes Mellitus, Type 2 Drug Therapy Metformin Administration & Dosage Adverse Effects Purines Quinazolines Animals Blood Drug Combinations Humans Hypoglycemic Agents Linagliptin Randomized Controlled Trials As Topic Methods Treatment Outcome Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology (medical) |
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