NDLI: Stability of 11 prevalent synthetic cannabinoids in authentic neat oral fluid samples: glass versus polypropylene containers at different temperatures.

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Stability of 11 prevalent synthetic cannabinoids in authentic neat oral fluid samples: glass versus polypropylene containers at different temperatures.

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Stability of 11 prevalent synthetic cannabinoids in authentic neat oral fluid samples: glass versus polypropylene containers at different temperatures.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kneisel, Stefan Speck, Michael Moosmann, Bjoern Auwärter, Volker
Description	Country affiliation: Germany Author Affiliation: Kneisel S ( Institute of Forensic Medicine, University Medical Center Freiburg, Albertstr. 9, 79104, Freiburg, Germany.)
Abstract	Although synthetic cannabinoids have been intensively investigated in recent years and oral fluid testing is becoming increasingly popular in suspected driving under the influence of drugs cases, only scarce data on their stability in authentic neat oral fluid (nOF) samples are yet available. However, especially for these new psychoactive drugs, investigations focusing on stability issues are necessary as inappropriate storage conditions may lead to considerable analytical problems. Since it has been shown for Δ(9) -tetrahydrocannabinol that adsorption to plastic surfaces may lead to considerable drug loss, we aimed to evaluate whether adsorption also has to be taken into account for synthetic cannabinoids in nOF samples. In this paper, the results of investigations on the recovery of 11 prevalent synthetic cannabinoids from authentic nOF samples stored over 72 h in RapidEASE (high quality borosilicate glass) and Sciteck Saliva Split Collector (polypropylene) tubes at 4 and 25 °C are presented. Our findings clearly demonstrate that lipophilic synthetic cannabinoids present in nOF samples adsorb to the surface of polypropylene containers when stored at room temperature, leading to considerable drug loss. Hence, when using polypropylene tubes, samples should be shipped cooled in order to avoid a substantial decrease of the analyte concentration during transportation.
File Format	HTM / HTML
ISSN	19427603
Issue Number	7
Volume Number	5
e-ISSN	19427611
Journal	Drug Testing and Analysis
Language	English
Publisher	Wiley
Publisher Date	2013-07-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology Cannabinoids Analysis Drug Packaging Standards Glass Polypropylenes Saliva Chemistry Temperature Methods Drug Stability Humans Comparative Study Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Spectroscopy Environmental Chemistry Analytical Chemistry Pharmaceutical Science

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Current knowledge on cannabinoids in oral fluid.

Current Knowledge on Cannabinoids in Oral Fluid

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Current knowledge on cannabinoids in oral fluid.

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Screening adulteration of polypropylene bottles with postconsumer recycled plastics for oral drug package by near-infrared spectroscopy.

Oral fluid cannabinoids in chronic frequent cannabis smokers during ad libitum cannabis smoking.

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