NDLI: Pharmacological treatments for acute respiratory distress syndrome.

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Pharmacological treatments for acute respiratory distress syndrome.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Frank, Angela J. Thompson, B. Taylor
Description	Country affiliation: United States Author Affiliation: Frank AJ ( Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.)
Abstract	PURPOSE OF REVIEW: Studies of the pharmacologic management of acute respiratory distress syndrome (ARDS) have yielded conflicting results. The purpose of this review is to discuss recent pharmacologic trials in ARDS, using the conceptual framework of ARDS as a heterogeneous disease. RECENT FINDINGS: Whereas most drug trials in ARDS have been negative, some studies suggest that targeting therapies at subgroups of patients may be successful. Proposed subgroups include early versus late-phase ARDS, direct versus indirect lung injury, and patients with altered coagulation. Corticosteroids have beneficial short-term effects when given at low or moderate doses sooner than 2 weeks but appear to be harmful if initiated later and are of unclear benefit if lung protective ventilation is also used. Surfactant may be helpful in patients with direct lung injury. Anticoagulants and vasodilators may have a greater chance for success in the subset of patients with vascular disease and a high dead-space fraction may identify such a population. SUMMARY: ARDS is a heterogeneous syndrome. Failure to target subgroups more likely to benefit from specific therapies may be one explanation for largely disappointing trial results so far.
File Format	HTM / HTML
ISSN	10705295
Issue Number	1
Volume Number	16
e-ISSN	15317072
Journal	Current Opinion in Critical Care
Language	English
Publisher	Lippincott Williams & Wilkins
Publisher Date	2010-02-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Critical Care Respiratory Distress Syndrome, Adult Drug Therapy Adrenal Cortex Hormones Pharmacology Therapeutic Use Biological Markers Clinical Trials As Topic Humans Lung Injury Proteinase Inhibitory Proteins, Secretory Physiopathology Journal Article Review
Content Type	Text
Resource Type	Article
Subject	Critical Care and Intensive Care Medicine

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