NDLI: The potential efficacy of noninvasive ventilation with administration of a neutrophil elastase inhibitor for acute respiratory distress syndrome.

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The potential efficacy of noninvasive ventilation with administration of a neutrophil elastase inhibitor for acute respiratory distress syndrome.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Tsushima, Kenji Yokoyama, Toshiki Matsumura, Takuya Koizumi, Tomonobu Kubo, Keishi Tatsumi, Koichiro
Description	Author Affiliation: Tsushima K ( First Department of Internal Medicine, Shinshu University School of Medicine, 3-1-1 Asahi Matsumoto Nagano 390-8621 Japan); Yokoyama T ( First Department of Internal Medicine, Shinshu University School of Medicine, 3-1-1 Asahi Matsumoto Nagano 390-8621 Japan.); Matsumura T ( Department of Respirology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana Chuo-ku Chiba 260-8670 Japan.); Koizumi T ( First Department of Internal Medicine, Shinshu University School of Medicine, 3-1-1 Asahi Matsumoto Nagano 390-8621 Japan.); Kubo K ( First Department of Internal Medicine, Shinshu University School of Medicine, 3-1-1 Asahi Matsumoto Nagano 390-8621 Japan.); Tatsumi K ( Department of Respirology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana Chuo-ku Chiba 260-8670 Japan.)
Abstract	PURPOSE: Noninvasive ventilation (NIV) can reduce the need for invasive mechanical ventilation. The aim of this investigation was to determine whether the combination of NIV with administration of a neutrophil elastase inhibitor could improve outcome and respiratory conditions in acute respiratory distress syndrome (ARDS)-patients, according to the Berlin definition. METHODS: ARDS-patients were treated with NIV and a neutrophil elastase inhibitor. Patients were classified as having mild, moderate, and severe ARDS. ARDS-patients were divided into survivors and nonsurvivors on day 28 after the induction of NIV. RESULTS: A total of 47 ARDS-patients received NIV, and 37 of these patients did not require endotracheal intubation. Eight mild, 17 moderate, and 10 severe ARDS-patients were alive on day 28 after the induction of NIV. When ARDS-patients were divided into groups based upon an initial PaO2/FiO2 greater or less than 150 torr, the serial changes of both the PaO2/FiO2 and the lung injury score improved dramatically in those patients with a PaO2/FiO2>150. The survival ratio showed statistically significant differences in mild and moderate ARDS-patients treated with the neutrophil elastase inhibitor. CONCLUSIONS: Administration of neutrophil elastase inhibitor with NIV may be associated with successful outcome in mild-to-moderate ARDS-patients with initial PaO2/FiO2>150.
File Format	HTM / HTML
ISSN	08839441
Issue Number	3
Volume Number	29
e-ISSN	15578615
Journal	Journal of Critical Care
Language	English
Publisher	Elsevier
Publisher Date	2014-06-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Critical Care Noninvasive Ventilation Proteinase Inhibitory Proteins, Secretory Therapeutic Use Respiratory Distress Syndrome, Adult Therapy Age Factors Aged Female Humans Intubation, Intratracheal Utilization Lung Injury Diagnosis Male Middle Aged Mortality Respiration, Artificial Classification Severity Of Illness Index Treatment Outcome Journal Article
Content Type	Text
Resource Type	Article
Subject	Critical Care and Intensive Care Medicine

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