NDLI: Infectious intracranial complications in the neuro-ICU patient population.

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Infectious intracranial complications in the neuro-ICU patient population.

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Infectious intracranial complications in the neuro-ICU patient population.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Beer, Ronny Pfausler, Bettina Schmutzhard, Erich
Description	Country affiliation: Austria Author Affiliation: Beer R ( Neurological Intensive Care Unit, Department of Neurology, Innsbruck Medical University, Innsbruck, Austria.)
Abstract	PURPOSE OF REVIEW: To provide an overview of infectious intracranial complications secondary to invasive procedures or trauma in the neuro-ICU patient population. Nosocomial infections of the central nervous system are a serious complication contributing to morbidity, prolonged length of stay in the ICU and/or hospital, and mortality of neurocritical care patients. RECENT FINDINGS: Any type of neurosurgical interventions, specifically ventriculostomy/external ventricular drainage, constitutes a major risk factor for infectious intracranial complications. Other predisposing factors are comorbidities with immunocompromised state and the presence of a distant focus of infection. The emergence of multiresistant pathogens adds to the complexity of the management of infectious intracranial complications. In recent years, several antimicrobial agents suitable for the treatment of nosocomial central nervous system infections have been extensively studied with respect to pharmacodynamics and pharmacokinetics in serum and - of special importance in the neurocritical care setting - cerebrospinal fluid. SUMMARY: Despite recent advances in prevention and treatment, the management of nosocomial intracranial infections still poses a challenge to the neuro-ICU specialist and must consider timely diagnosis and prompt initiation of appropriate antibiotic therapy. This review focuses on the definition, epidemiology, clinical features, and therapeutical approach to this distinct complication of neurocritical care.
File Format	HTM / HTML
ISSN	10705295
Issue Number	2
Volume Number	16
e-ISSN	15317072
Journal	Current Opinion in Critical Care
Language	English
Publisher	Lippincott Williams & Wilkins
Publisher Date	2010-04-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Critical Care Central Nervous System Infections Diagnosis Critical Care Methods Cross Infection Intensive Care Units Meningitis, Bacterial Anti-bacterial Agents Therapeutic Use Drug Therapy Pathology Humans Risk Factors Time Factors Journal Article Review
Content Type	Text
Resource Type	Article
Subject	Critical Care and Intensive Care Medicine

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