NDLI: Submicron scale-structured hydrophilic titanium surfaces promote early osteogenic gene response for cell adhesion and cell differentiation.

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Submicron scale-structured hydrophilic titanium surfaces promote early osteogenic gene response for cell adhesion and cell differentiation.

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Submicron scale-structured hydrophilic titanium surfaces promote early osteogenic gene response for cell adhesion and cell differentiation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Klein, Marcus Oliver Bijelic, Ana Ziebart, Thomas Koch, Felix Kämmerer, Peer W. Wieland, Marco Konerding, Moritz A. Al-Nawas, Bilal
Description	Country affiliation: Germany Author Affiliation: Klein MO ( Oral and Maxillofacial Surgery, University Medicine Mainz, Mainz, Germany. klein@mkg.klinik.uni-mainz.de)
Abstract	BACKGROUND AND PURPOSE: Titanium (Ti) surface roughness and surface hydrophilicity are key factors to regulate osteogenic cell responses during dental implant healing. In detail, specific integrin-mediated interactions with the extracellular environment trigger relevant osteogenic cell responses like differentiation and matrix synthesis via transcriptions factors. Aim of this study was to monitor surface-dependent osteogenic cell adhesion dynamics, proliferation, and specific osteogenic cell differentiation over a period of 7 days. MATERIALS AND METHODS: Ti disks were manufactured to present smooth pretreatment (PT) surfaces and rough sandblasted/acid-etched (SLA) surfaces. Further processing to isolate the uncontaminated TiO(2) surface from contact with atmosphere provided a highly hydrophilic surface without alteration of the surface topography (modSLA). Tissue culture polystyrene (TCPS) served as control. Human osteogenic cells were cultivated on the respective substrates. After 24 hours, 48 hours, 72 hours, and 7 days, cell morphology on the Ti substrates was visualized by scanning transmission electron microscopy. As a marker of cellular proliferation, cell count was assessed. For the analysis of cell adhesion and differentiation, specific gene expression levels of the integrin subunits ß1 and v, runx-2, collagen type I (COL), alkaline phosphatase (AP), and osteocalcin (OC) were obtained by real-time RT-PCR for the respective time points. Data were normalized to internal controls. RESULTS: TCPS and PT surfaces preserved a rather immature, dividing osteogenic phenotype (high proliferation rates, low integrin levels, and low specific osteogenic cell differentiation). SLA and especially modSLA surfaces promoted both cell adhesion as well as the maturation of osteogenic precursors into post-mitotic osteoblasts. In detail, during the first 48 hours, modSLA resulted in lowest cell proliferation rates but exhibited highest levels of the investigated integrins, runx-2, COL, AP, and OC. CONCLUSION: Our results revealed a strong synergistic effect between submicron-scale roughness and surface hydrophilicity on early osteogenic cell adhesion and maturation.
File Format	HTM / HTML
ISSN	15230899
Issue Number	2
Volume Number	15
e-ISSN	17088208
Journal	Clinical Implant Dentistry and Related Research
Language	English
Publisher	Wiley
Publisher Date	2013-04-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Dentistry Dental Materials Chemistry Osteoblasts Physiology Osteogenesis Genetics Titanium Acid Etching, Dental Methods Alkaline Phosphatase Analysis Antigens, Cd29 Cell Adhesion Cell Count Cell Culture Techniques Cell Differentiation Cell Proliferation Cell Shape Cells, Cultured Collagen Type I Core Binding Factor Alpha 1 Subunit Dental Etching Humans Hydrophobic And Hydrophilic Interactions Integrin Alphav Microscopy, Electron, Scanning Transmission Osteocalcin Phenotype Polystyrenes Surface Properties Time Factors Journal Article
Content Type	Text
Resource Type	Article
Subject	Oral Surgery

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