NDLI: Titanium nitride oxide coating on rough titanium stimulates the proliferation of human primary osteoblasts.

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Titanium nitride oxide coating on rough titanium stimulates the proliferation of human primary osteoblasts.

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Titanium nitride oxide coating on rough titanium stimulates the proliferation of human primary osteoblasts.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Durual, S. Pernet, F. Rieder, P. Mekki, M. Cattani-Lorente, M. Wiskott, H. W. A.
Description	Country affiliation: Switzerland Author Affiliation: Durual S ( Laboratory of Biomaterials, University of Geneva, Switzerland. stephane.durual@unige.ch)
Abstract	OBJECTIVES: Titanium is widely used in contemporary endosseous implantology and there is considerable thrust to further promote osseointegration by implant surface modifications. The aim of this study was to evaluate the effect of a titanium-nitride-oxide (TiNOx) coating on commercially pure microroughened titanium by assessing the proliferation and differentiation of human primary osteoblasts. MATERIALS AND METHODS: Cell proliferation, gene expression, alkaline phosphatase activity, osteoprotegerin and osteocalcin secretion were analyzed for a time course of 3 weeks, with or without additional stimulation by 1.25(OH)(2) vitamin D(3) 100 nM. RESULTS: A 1.5-fold increase in the proliferation rate of cells grown on TiNOx-coated titanium as compared with uncoated surfaces was observed. SEM views indicated that the cells' normal morphology with their numerous extensions was maintained. The differentiation process on the TiNOx surface was only affected to a minor degree and translated into a slight delay in osteoblast maturation when compared to uncoated titanium. CONCLUSION: Pending confirmation of these results in vivo, TiNOx coatings could potentially accelerate and enhance osseointegration.
File Format	HTM / HTML
ISSN	09057161
Issue Number	5
Volume Number	22
e-ISSN	16000501
Journal	Clinical Oral Implants Research
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2011-05-01
Publisher Place	Denmark
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Dentistry Discipline General Surgery Alloys Chemistry Coated Materials, Biocompatible Dental Materials Osteoblasts Physiology Titanium Acid Etching, Dental Methods Alkaline Phosphatase Analysis Aluminum Oxide Calcitriol Pharmacology Calcium Channel Agonists Cell Adhesion Cell Count Cell Differentiation Drug Effects Cell Proliferation Cells, Cultured Dental Etching Gene Expression Regulation Humans Hydrochloric Acid Microscopy, Electron, Scanning Osteocalcin Osteoprotegerin Photoelectron Spectroscopy Plasma Gases Reverse Transcriptase Polymerase Chain Reaction Surface Properties Comparative Study Journal Article
Content Type	Text
Resource Type	Article
Subject	Oral Surgery

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