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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Walter, Thomas Szabo, Sebastian Suselbeck, Tim Borggrefe, Martin Lang, Siegfried Swoboda, Stefanie Hoffmeister, Hans Martin Dempfle, Carl-Erik |
| Description | Country affiliation: Germany Author Affiliation: Walter T ( University Medical Center Mannheim, First Department of Medicine, Mannheim, Germany.) |
| Abstract | BACKGROUND: Treatment with HMG-CoA reductase inhibitors (statins) reduces the morbidity and mortality of coronary artery disease (CAD). In addition to their lipid-lowering actions, pleiotropic effects of statins have been demonstrated. OBJECTIVE: The aim of the present study was to assess if atorvastatin therapy has an impact on haemostasis, fibrinolysis and inflammation in normocholesterolaemic patients with CAD. METHODS: Fifty-four patients with CAD who had received atorvastatin treatment for at least 8 weeks (mean dosage 30 mg/day) and 54 patients with CAD who had not received atorvastatin therapy were selected from a larger prospective, randomized, double-blind study for inclusion in this post hoc analysis. Patients were matched by their total cholesterol levels. All patients were normocholesterolaemic. RESULTS: In the atorvastatin-treated patients significantly lower plasma levels of thrombin-antithrombin complexes (p < 0.05), plasminogen activator inhibitor-1 activity (PAI-1) [p < 0.05], soluble vascular cell adhesion molecule-1 (p < 0.05), soluble platelet selectin (p < 0.05) and high-sensitivity C-reactive protein (p < 0.05) were measured compared with patients not on atorvastatin therapy. Additionally, a strong trend towards lower soluble intercellular adhesion molecule-1 plasma levels was detected in patients treated with atorvastatin. No differences were found in tissue-type plasminogen activator antigen, plasmin-plasmin inhibitor complexes, fibrinogen, D-dimer and activated factor XII values. CONCLUSION: Atorvastatin appears to have an effect on coagulation activation, fibrinolysis and inflammation in patients with CAD. Reduction in PAI-1 and reduced thrombin formation may have an impact on cardiovascular morbidity and mortality in patients with CAD. |
| File Format | HTM / HTML |
| ISSN | 11732563 |
| Issue Number | 7 |
| Volume Number | 30 |
| e-ISSN | 11791918 |
| Journal | Clinical Drug Investigation |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2010-01-01 |
| Publisher Place | New Zealand (Aotearoa) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Coronary Artery Disease Drug Therapy Heptanoic Acids Pharmacology Hydroxymethylglutaryl-coa Reductase Inhibitors Pyrroles Aged Atorvastatin Calcium Physiopathology Double-blind Method Female Fibrinolysis Drug Effects Hemostasis Humans Inflammation Etiology Male Middle Aged Plasminogen Activator Inhibitor 1 Blood Randomized Controlled Trials As Topic Thrombin Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology (medical) |
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