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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lai, Shih-Wei Lin, Cheng-Li Liao, Kuan-Fu |
| Spatial Coverage | Taiwan |
| Description | Country affiliation: Taiwan Author Affiliation: Lai SW ( College of Medicine, China Medical University, Taichung City, Taiwan. wei@mail.cmuh.org.tw.); Lin CL ( Department of Family Medicine, China Medical University Hospital, Taichung City, Taiwan. wei@mail.cmuh.org.tw.); Liao KF ( College of Medicine, China Medical University, Taichung City, Taiwan. orangechengli@gmail.com.) |
| Abstract | BACKGROUND AND OBJECTIVE: No sufficient research has focused on the relationship between meloxicam use and acute pancreatitis. This study aimed to explore this issue in Taiwan. METHODS: This case-control study was conducted using the database of the Taiwan National Health Insurance Program. In all, there were 6780 cases aged 20-84 years who were newly diagnosed with acute pancreatitis during the period 1998-2011, and 21,393 control subjects without acute pancreatitis. Cases and controls were matched for sex, age and comorbidities. Odds ratios (ORs) and 95% confidence intervals (CIs) were measured to explore the associations between acute pancreatitis, meloxicam use and comorbidities, using a multivariable unconditional logistic regression model. RESULTS: After controlling for potential confounding factors, the adjusted OR for acute pancreatitis was 1.76 (95% CI 1.30-2.40) for subjects with current use of meloxicam, in comparison with subjects who had never used meloxicam. The adjusted OR decreased to 1.29 (95% CI 0.82-2.03) for subjects with late use of meloxicam, but without statistical significance. CONCLUSIONS: Current use of meloxicam is associated with increased odds of acute pancreatitis. Clinicians should consider the potential risk of acute pancreatitis when prescribing meloxicam. |
| File Format | HTM / HTML |
| ISSN | 11732563 |
| Issue Number | 10 |
| Volume Number | 35 |
| e-ISSN | 11791918 |
| Journal | Clinical Drug Investigation |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2015-10-01 |
| Publisher Place | New Zealand (Aotearoa) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Alcohol-related Disorders Epidemiology Gallstones Pancreatitis Thiazines Adverse Effects Thiazoles Adult Aged Aged, 80 And Over Case-control Studies Comorbidity Databases, Factual Female Chemically Induced Humans Male Middle Aged Risk Factors Taiwan Young Adult Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology (medical) |
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