NDLI: Association between sepsis and dementia.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kao, Li-Ting Sheu, Jau-Jiuan Lin, Herng-Ching Tsai, Ming-Chieh Chung, Shiu-Dong
Spatial Coverage	Taiwan
Description	Country affiliation: Taiwan Author Affiliation: Kao LT ( Graduate Institute of Life Science, National Defense Medical Center, Taipei, Taiwan); Sheu JJ ( Department of Neurology, Taipei Medical University Hospital, Taipei, Taiwan); Lin HC ( School of Health Care Administration, Taipei Medical University, 250 Wu-Hsin Street, Taipei 110, Taiwan); Tsai MC ( School of Health Care Administration, Taipei Medical University, 250 Wu-Hsin Street, Taipei 110, Taiwan); Chung SD ( Sleep Research Center, Taipei Medical University Hospital, Taipei, Taiwan)
Abstract	In this study, we explored the association between sepsis and dementia using a population-based dataset in Taiwan and a case-control design. The relationship between severe systemic infections and dementia is still unclear. Data for this case-control study were taken from the Taiwan Longitudinal Health Insurance Database 2000. This study included 5955 patients with dementia and 5955 sex and age-matched healthy controls. We performed conditional logistic regressions to examine the association of dementia with previously diagnosed sepsis. We found that 168 (1.41%) of the sampled people had been hospitalized for treatment of sepsis before the index date, 122 patients (2.05%) and 46 controls (0.77%; p<0.001). The conditional logistic regression indicated that patients with dementia were more likely to have been previously diagnosed with sepsis than controls after adjusting for monthly income, urbanization level, hyperlipidemia, and diabetes (odds ratio [OR] 2.60; 95% confidence interval [CI] 1.84-3.66). We also found that dementia was associated with prior sepsis regardless of sex (males: adjusted OR 3.17; 95% CI 1.76-5.68; females: adjusted OR 2.27; 95% CI 1.48-3.47). We concluded that patients with dementia had a higher odds of previous sepsis compared to the control group.
File Format	HTM / HTML
ISSN	09675868
Issue Number	9
Volume Number	22
e-ISSN	15322653
Journal	Journal of Clinical Neuroscience
Language	English
Publisher	Elsevier
Publisher Date	2015-09-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Medicine Dementia Epidemiology Sepsis Complications Adult Aged Aged, 80 And Over Case-control Studies Databases, Factual Etiology Female Humans Logistic Models Male Middle Aged Odds Ratio Taiwan Journal Article
Content Type	Text
Resource Type	Article
Subject	Neurology Physiology (medical) Neurology (clinical) Surgery

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