NDLI: Association of genetic variants and incident coronary heart disease in multiethnic cohorts: the PAGE study.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Franceschini, Nora Carty, Cara Buzková, Petra Reiner, Alex P. Garrett, Tiana Lin, Yi Vöckler, Jens-S Hindorff, Lucia A. Cole, Shelley A. Boerwinkle, Eric Lin, Dan-Yu Bookman, Ebony Best, Lyle G. Bella, Jonathan N. Eaton, Charles Greenland, Philip Jenny, Nancy North, Kari E. Taverna, Darin Young, Alicia M. Deelman, Ewa Kooperberg, Charles Psaty, Bruce Heiss, Gerardo
Description	Country affiliation: United States Author Affiliation: Franceschini N ( Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.)
Abstract	BACKGROUND: Genome-wide association studies identified several single nucleotide polymorphisms (SNP) associated with prevalent coronary heart disease (CHD), but less is known of associations with incident CHD. The association of 13 published CHD SNPs was examined in 5 ancestry groups of 4 large US prospective cohorts. METHODS AND RESULTS: The analyses included incident coronary events over an average 9.1 to 15.7 follow-up person-years in up to 26 617 white individuals (6626 events), 8018 black individuals (914 events), 1903 Hispanic individuals (113 events), 3669 American Indian individuals (595 events), and 885 Asian/Pacific Islander individuals (66 events). We used Cox proportional hazards models (with additive mode of inheritance) adjusted for age, sex, and ancestry (as needed). Nine loci were statistically associated with incident CHD events in white participants: 9p21 (rs10757278; P=4.7 × 10(-41)), 16q23.1 (rs2549513; P=0.0004), 6p24.1 (rs499818; P=0.0002), 2q36.3 (rs2943634; P=6.7 × 10(-6)), MTHFD1L (rs6922269, P=5.1 × 10(-10)), APOE (rs429358; P=2.7×10(-18)), ZNF627 (rs4804611; P=5.0 × 10(-8)), CXCL12 (rs501120; P=1.4 × 10(-6)) and LPL (rs268; P=2.7 × 10(-17)). The 9p21 region showed significant between-study heterogeneity, with larger effects in individuals age 55 years or younger and in women. Inclusion of coronary revascularization procedures among the incident CHD events introduced heterogeneity. The SNPs were not associated with CHD in black participants, and associations varied in other US minorities. CONCLUSIONS: Prospective analyses of white participants replicated several reported cross-sectional CHD-SNP associations.
File Format	HTM / HTML
ISSN	1942325X
e-ISSN	19423268
DOI	10.1161/CIRCGENETICS.111.960096
Journal	Circulation: Cardiovascular Genetics
Issue Number	6
Volume Number	4
Language	English
Publisher	American Heart Association
Publisher Date	2011-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Cardiology Continental Population Groups Genetics Coronary Disease Ethnology Genome-wide Association Study Polymorphism, Single Nucleotide Prospective Studies Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Genetics Genetics (clinical) Cardiology and Cardiovascular Medicine

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