NDLI: Cardiac hypertrophy in deceased users of anabolic androgenic steroids: an investigation of autopsy findings.

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Cardiac hypertrophy in deceased users of anabolic androgenic steroids: an investigation of autopsy findings.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Far, Hamid Reza Mobini Ågren, Greta Thiblin, Ingemar
Spatial Coverage	Sweden
Description	Country affiliation: Sweden Author Affiliation: Far HR ( Department of Surgical Science, Division of Forensic Medicine, Uppsala University, Uppsala, Sweden.)
Abstract	BACKGROUND: The use of anabolic androgenic steroids (AASs) has been associated with hypertrophy of the left cardiac ventricle (LVH) as diagnosed by echocardiography. Case reports suggest that AAS-related LVH may lead to sudden death. We performed an investigation of the gross cardiac pathological findings in deceased male AAS users in order to further elucidate the proposed role of AAS in cardiac hypertrophy. METHODS: Eighty-seven deceased males who tested positive for AAS at autopsy and 173 age-adjusted control deceased males without suspected AAS use were studied for cardiac hypertrophy. The AAS-positive subjects had been examined at any of the six departments of forensic medicine in Sweden during the period from 1989 to 2009. Data were assessed employing multivariate analyses controlling for body weight, height, age, bleeding after trauma, and the impact of weight training. RESULTS: The analysis of the logarithm of heart mass by multivariate statistics implied that strong correlations existed between body mass and heart mass (P<.00001), height and heart mass (P<.02), age and heart mass (P<.00001), and trauma (bleeding) and heart mass (P=.00001). After controlling for these factors, a significantly higher heart mass (P=.0001) was found among the AAS-positive males. CONCLUSION: Our findings suggest that use of AAS may lead to cardiac hypertrophy with a direct cardiotropic effect.
File Format	HTM / HTML
ISSN	10548807
Issue Number	4
Volume Number	21
e-ISSN	18791336
Journal	Cardiovascular Pathology
Language	English
Publisher	Elsevier
Publisher Date	2012-07-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Cardiology Discipline Pathology Anabolic Agents Adverse Effects Androgens Autopsy Hypertrophy, Left Ventricular Chemically Induced Substance-related Disorders Etiology Body Weight Cause Of Death Death, Sudden Forensic Pathology Heart Drug Effects Humans Diagnosis Mortality Male Myocardium Pathology Organ Size Sweden Epidemiology Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Pathology and Forensic Medicine Cardiology and Cardiovascular Medicine

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