NDLI: Evidence of Altered Cardiac Electrophysiology Following Prolonged Androgenic Anabolic Steroid Use

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Evidence of Altered Cardiac Electrophysiology Following Prolonged Androgenic Anabolic Steroid Use

Content Provider	Springer Nature Link
Author	Sculthorpe, Nicholas Grace, Fergal Jones, Peter Davies, Bruce
Copyright Year	2010
Abstract	The non-therapeutic use of androgenic anabolic steroids (AAS) is associated with sudden cardiac death. Despite this, there is no proposed mechanism by which this may occur. Signal-averaged ECG (SAECG) allows the assessment of cardiac electrical stability, reductions of which are a known risk factor for cardiac arrhythmias. The aim of the present study was to examine cardiac electrical stability using SAECG in a group (n = 15) of long-term AAS users (AAS use 21.3 ± 3.1 years) compared with a group (n = 15) of age-matched weight lifters (WL) and age-matched sedentary controls [C (n = 15)]. AS, WL and C underwent SAECG analysis at rest and following an acute bout of exercise to volitional exhaustion. SAECGs were analyzed using a 40 Hz filter and were averaged over 200 beats. Results indicate a non-significant trend for increased incidence of abnormal SAECG measures at rest in AS (P = 0.55). However, AS demonstrated a significantly higher incidence of abnormalities of SAECG following exercise than C or WL (P < 0.05). In conclusion, the higher incidence of abnormal SAECG measurements immediately post-exercise in the AAS group places them at a greater risk of sudden death. The present study provides a strong contraindication to the use of AAS.
Starting Page	239
Ending Page	243
Page Count	5
File Format	PDF
ISSN	15307905
Journal	Cardiovascular Toxicology
Volume Number	10
Issue Number	4
e-ISSN	15590259
Language	English
Publisher	Humana Press Inc
Publisher Date	2010-10-31
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Late ventricular potentials (LPs) Androgenic anabolic steroids (AAS) Signal-averaged electrocardiogram (SAECG) arrhythmias Sudden cardiac death (SCD) Left ventricular hypertrophy (LVH) Cardiology Pharmacology/Toxicology
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Toxicology Cardiology and Cardiovascular Medicine

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