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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hsu, Fu-Yin Lu, Meng-Ru Weng, Ru-Chun Lin, Hsiu-Mei |
| Description | Country affiliation: Taiwan Author Affiliation: Hsu FY ( Department of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung, Taiwan.) |
| Abstract | Mesoporous bioactive glass nanofibers (MBGNFs) were prepared by a sol-gel/electrospinning technique. Subsequently, a collagen-MBGNF (CM) composite scaffold that simultaneously possessed a macroporous structure and collagen nanofibers was fabricated by a gelation and freeze-drying process. Additionally, immersing the CM scaffold in a simulated body fluid resulted in the formation of bone-like apatite minerals on the surface. The CM scaffold provided a suitable environment for attachment to the cytoskeleton. Based on the measured alkaline phosphatase activity and protein expression levels of osteocalcin and bone sialoprotein, the CM scaffold promoted the differentiation and mineralization of MG63 osteoblast-like cells. In addition, the bone regeneration ability of the CM scaffold was examined using a rat calvarial defect model in vivo. The results revealed that CM is biodegradable and could promote bone regeneration. Therefore, a CM composite scaffold is a potential bone graft for bone tissue engineering applications. |
| File Format | HTM / HTML |
| ISSN | 17486041 |
| e-ISSN | 1748605X |
| Journal | Biomedical Materials |
| Issue Number | 2 |
| Volume Number | 10 |
| Language | English |
| Publisher | IOP Publishing |
| Publisher Date | 2015-03-25 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Discipline Biomedical Engineering Biomimetic Materials Chemistry Bone Substitutes Tissue Scaffolds Alkaline Phosphatase Metabolism Animals Bone Regeneration Cell Line Collagen Materials Testing Nanofibers Ultrastructure Osteoblasts Cytology Physiology Rats, Sprague-dawley Skull Injuries Tissue Engineering Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Business and International Management Mechanics of Materials Biomaterials Bioengineering Biomedical Engineering |
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