NDLI: Pharmacokinetics of bromide in adult sheep following oral and intravenous administration.

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Pharmacokinetics of bromide in adult sheep following oral and intravenous administration.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Quast, T. A. Combs, M. D. Edwards, S. H.
Description	Country affiliation: Australia Author Affiliation: Quast TA ( School of Animal and Veterinary Science, Charles Sturt University, Wagga Wagga, New South Wales, Australia.)
Abstract	OBJECTIVE: To determine the pharmacokinetics of bromide in sheep after single intravenous (IV) and oral (PO) doses. PROCEDURE: Sixteen Merino sheep were randomly assigned to two treatment groups and given 120 mg/kg bromide, as sodium bromide IV or potassium bromide PO. Serum bromide concentrations were determined by colorimetric spectrophotometry. RESULTS: After IV administration the maximum concentration (Cmax ) was 822.11 ± 93.61 mg/L, volume of distribution (Vd ) was 0.286 ± 0.031 L/kg and the clearance (Cl) was 0.836 ± 0.255 mL/h/kg. After PO administration the Cmax was 453.86 ± 43.37 mg/L and the time of maximum concentration (Tmax ) was 108 ± 125 h. The terminal half-life (t½ ) of bromide after IV and PO administration was 387.93 ± 115.35 h and 346.72 ± 94.05 h, respectively. The oral bioavailability (F) of bromide was 92%. No adverse reactions were noted in either treatment group during this study. The concentration versus time profiles exhibited secondary peaks, suggestive of gastrointestinal cyclic redistribution of the drug. CONCLUSIONS AND CLINICAL RELEVANCE: When administered PO, bromide in sheep has a long half-life (t½ ) of approximately 14 days, with good bioavailability. Potassium bromide is a readily available, affordable salt with a long history of medical use as an anxiolytic, sedative and antiseizure therapy in other species. There are a number of husbandry activities and flock level neurological conditions, including perennial ryegrass toxicosis, in which bromide may have therapeutic or prophylactic application.
File Format	HTM / HTML
ISSN	00050423
Issue Number	1-2
Volume Number	93
e-ISSN	17510813
Journal	Australian Veterinary Journal
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2015-01-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Veterinary Medicine Bromides Pharmacokinetics Potassium Compounds Sheep Metabolism Sodium Compounds Administration, Intravenous Veterinary Administration, Oral Animals Administration & Dosage Blood Female Half-life Random Allocation Spectrophotometry Methods Journal Article
Content Type	Text
Resource Type	Article
Subject	Veterinary Medicine

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