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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Rochet, Nicole M. Kottschade, Lisa A. Grotz, Travis E. Porrata, Luis F. Markovic, Svetomir N. |
| Description | Country affiliation: Mongolia Author Affiliation: Rochet NM ( Departments of *Medical Oncology Surgery Medicine, Division of Hematology, Mayo Clinic College of Medicine, Rochester, MN.) |
| Abstract | OBJECTIVES: Published data have reported that components of the peripheral blood are significant prognostic factors in hematologic and solid malignancies. Thus, we sought to investigate if the preoperative absolute lymphocyte count (ALC) and absolute monocyte count (AMC) affects disease progression and survival after complete surgical resection of advanced malignant melanoma. METHODS: We retrospectively reviewed records of 227 patients with resected advanced malignant melanoma (153 stage III and 74 stage IV) that were treated at the Mayo Clinic from 2000 to 2010. Survival analysis was performed using the Kaplan-Meier method, log-rank tests, and the Cox proportional hazards model for the univariate and multivariate analysis. RESULTS: Surgically resected stage III melanoma patients with a preoperative AMC<0.6×10/L experienced a longer overall survival (OS) versus AMC≥0.6×10/L (median: 63.9 vs. 34.8 mo, respectively, P<0.008). Multivariate analysis showed AMC to be an independent predictor for OS in stage III patients. Stage IV resected melanoma patients with an ALC≥1.9×10/L experienced a superior median relapse-free survival (RFS) compared with patients with an ALC<1.9×10/L (median: 11.4 vs. 5.4 mo, respectively, P<0.006). Multivariate analysis showed ALC to be an independent predictor for RFS in stage IV patients. CONCLUSIONS: These data showed that in surgically resected stage III melanoma, preoperative AMC is an independent prognostic factor for OS. In contrast, a higher preoperative ALC is an independent prognostic for longer RFS in surgically resected stage IV melanoma. |
| File Format | HTM / HTML |
| ISSN | 02773732 |
| e-ISSN | 1537453X |
| DOI | 10.1097/COC.0b013e31829b5605 |
| Journal | American Journal of Clinical Oncology |
| Issue Number | 3 |
| Volume Number | 38 |
| Language | English |
| Publisher | Lippincott Williams & Wilkins |
| Publisher Date | 2015-06-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Oncology Lymphocytes Melanoma Blood Pathology Monocytes Adolescent Disease Progression Disease-free Survival Leukocyte Count Lymphocyte Count Surgery Neoplasm Staging Preoperative Period Retrospective Studies Survival Rate Research Support, N.i.h., Extramural |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
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