| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Zhang, Y. Jiang, C. Li, J. Sun, J. Qu, X. |
| Description |
Author Affiliation: Zhang Y ( Institute of Basic Medical Sciences, Qilu Hospital, Shandong University, No. 107, Wen Hua Xi Road, Jinan, 250012, Shandong, People's Republic of China.); Jiang C ( Department of Pathology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, 266011, Shandong, China.); Li J ( Department of Pathology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, 266011, Shandong, China.); Sun J ( Central Laboratory, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, 266011, Shandong, China.); Qu X ( Institute of Basic Medical Sciences, Qilu Hospital, Shandong University, No. 107, Wen Hua Xi Road, Jinan, 250012, Shandong, People's Republic of China.) |
| Abstract |
PURPOSE: Neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) were immune response-related indicators. Preoperative NLR and PLR had been considered to be related to the prognosis of various cancers. The objective of this study was to evaluate the prognostic significance of NLR and PLR in patients with gallbladder carcinoma (GBC). METHODS: From 2001 to 2013, 145 patients with GBC were recruited in this retrospective study. Cutoff values of NLR and PLR were determined by receiver operating characteristic curves (ROC). The correlation of clinical data, including tumor differentiation, nevin stage, TNM stage, operation margin, operation mode, NLR, PLR, hemoglobin, C reactive protein (CRP), carcinoembryonic antigen (CEA), and carbohydrate antigen 199 (CA199) with median survival period of patients was analyzed by univariate survival analysis. The multivariate prognosis analysis was performed to select the independent prognostic factors. RESULTS: The cutoff values of NLR and PLR were 1.94 and 113.34, respectively. Compared with low NLR and low PLR group, the 5-year survival rates in high NLR and high PLR group were reduced (P < 0.05). The degree of tumor differentiation, nevin stage, TNM stage, operation mode, NLR, PLR, CA199, total bilirubin, CRP and CEA were associated with the median survival period of patients (P < 0.01). The multivariate prognosis analysis showed that NLR, nevin stage, operation mode and hemoglobin were independent prognostic factors (P < 0.05). CONCLUSION: Preoperative NLR and PLR were closely related to prognosis of patients with GBC and might be useful for the evaluation of prognosis of patients with GBC. |
| File Format |
HTM / HTML |
| ISSN |
1699048X |
| Issue Number |
10 |
| Volume Number |
17 |
| e-ISSN |
16993055 |
| Journal |
Clinical and Translational Oncology |
| Language |
English |
| Publisher |
Springer |
| Publisher Date |
2015-10-01 |
| Publisher Place |
Italy |
| Access Restriction |
One Nation One Subscription (ONOS) |
| Subject Keyword |
Discipline Oncology Adenocarcinoma Blood Blood Platelets Carcinoma, Adenosquamous Carcinoma, Squamous Cell Gallbladder Neoplasms Lymphocytes Neutrophils Pathology Surgery Aged C-reactive Protein Metabolism Ca-19-9 Antigen Carcinoembryonic Antigen Female Humans Leukocyte Count Lymphocyte Count Male Middle Aged Multivariate Analysis Neoplasm Staging Platelet Count Preoperative Period Prognosis Roc Curve Retrospective Studies Survival Analysis Journal Article |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Cancer Research Oncology |
