NDLI: Serum brain-derived neurotrophic factor levels in relation to comorbid depression and cytokine levels in Nepalese men with alcohol-use disorders.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Neupane, Sudan Prasad Lien, Lars Ueland, Thor Mollnes, Tom Eirik Aukrust, Pål Bramness, Jørgen G.
Spatial Coverage	Nepal
Description	Author Affiliation: Neupane SP ( SERAF-Norwegian Centre for Addiction Research, University of Oslo, Norway. Electronic address: s.p.neupane@medisin.uio.no.); Lien L ( SERAF-Norwegian Centre for Addiction Research, University of Oslo, Norway); Ueland T ( Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Norway); Mollnes TE ( KG. Jebsen Inflammatory Research Center, University of Oslo, Norway); Aukrust P ( Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Norway); Bramness JG ( SERAF-Norwegian Centre for Addiction Research, University of Oslo, Norway.)
Abstract	Neurodegenerative and inflammatory processes are involved separately in major depression (MD) and alcohol-use disorders (AUD). Little is known about the nature of this relationship in the context of comorbid AUD and depression disorders. In this study, we determined brain-derived neurotrophic factor (BDNF) serum levels in patients with AUD and tested whether BDNF levels were related to history of major depression, recent depressive symptoms, AUD severity, and TNF- and IL-6 levels. Nepalese male AUD inpatients (N=152) abstinent from alcohol for an average of 34 days were administered structured interviews to assess depression symptoms and pattern and extent of alcohol use, and to generate research diagnoses for AUD and MD. AUD severity was assessed by scores on the Alcohol Use Disorder Identification Test. Serum BDNF and cytokines were measured using ELISA and multiplex technology, respectively. Although serum BDNF levels were unrelated to MD history, patients with recent depressive symptoms (n=42) had lower (mean±SD) BDNF serum levels compared to those without (n=110) (21.6±8.1 ng/mL vs. 26.0±9.6 ng/mL; p=0.010), and patients with higher AUD severity and binge-drinking patterns had higher mean serum BDNF levels compared to lower AUD severity and non-binging (25.9±9.7 ng/mL vs. 22.1±8.7 ng/mL; p=0.022 and 25.7±9.3 vs. 21.8±9.7 ng/mL; p=0.029, respectively). Positive correlations were present between BDNF and TNF- (r=0.39, p<0.001) and IL-6 (r=0.2, p=0.027). In particular, TNF- levels were predictive of BDNF levels after controlling for confounders (B=0.3 [95% CI=0.2-0.5], p<0.001). These findings show that in alcohol-using populations, peripheral BDNF levels are related to severity of AUD as well as presence of depressive symptoms. The significant associations between inflammatory and neurotrophic factors may have implications for neuroadaptive changes during recovery from AUD.
File Format	HTM / HTML
ISSN	07418329
Issue Number	5
Volume Number	49
e-ISSN	18736823
Journal	Alcohol
Language	English
Publisher	Elsevier
Publisher Date	2015-08-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Substance-Related Disorders Alcohol-related Disorders Blood Epidemiology Brain-derived Neurotrophic Factor Cytokines Depression Adolescent Adult Comorbidity Humans Male Middle Aged Nepal Young Adult Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Neurology Medicine Behavioral Neuroscience Health (social science) Biochemistry Toxicology

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