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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Trantham-Davidson, Heather Chandler, L. Judson |
| Description | Author Affiliation: Trantham-Davidson H ( Department of Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA. Electronic address: tranthah@musc.edu.); Chandler LJ ( Department of Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA.) |
| Abstract | Long-term alcohol use leads to persistent cognitive deficits that may be associated with maladaptive changes in the neurocircuitry that mediates executive functions. Impairments caused by these changes can persist well into abstinence and have a negative impact on quality of life and job performance, and can increase the probability of relapse. Many of the changes that affect cognitive function appear to involve dysregulation of the mesocortical dopamine system. This includes changes in dopamine release and alterations in dopamine receptor expression and function in the medial prefrontal cortex (PFC). This review summarizes the cellular effects of acute and chronic ethanol exposure on dopamine release and dopamine receptor function in the PFC with the goal of providing greater understanding of the effects of alcohol-use disorders on the dopamine system and how this relates to deficits in the executive function of the PFC. |
| File Format | HTM / HTML |
| ISSN | 07418329 |
| Issue Number | 8 |
| Volume Number | 49 |
| e-ISSN | 18736823 |
| Journal | Alcohol |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-12-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Substance-Related Disorders Alcoholic Intoxication Metabolism Alcoholism Cognition Disorders Dopamine Neostriatum Prefrontal Cortex Receptors, Dopamine Physiopathology Psychology Animals Central Nervous System Depressants Pharmacology Ethanol Humans Drug Effects Neural Pathways Synaptic Transmission Journal Article Research Support, N.i.h., Extramural Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neurology Medicine Behavioral Neuroscience Health (social science) Biochemistry Toxicology |
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