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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Farris, Sean P. Pietrzykowski, Andrzej Z. Miles, Michael F. O'Brien, Megan A. Sanna, Pietro P. Zakhari, Samir Mayfield, R. Dayne Harris, R. Adron |
| Description | Country affiliation: United States Author Affiliation: Farris SP ( Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, 2500 Speedway, Austin, TX 78712, USA.); Pietrzykowski AZ ( Department of Animal Sciences, Rutgers University, New Brunswick, NJ, USA); Miles MF ( Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA.); O'Brien MA ( Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA.); Sanna PP ( Molecular and Cellular Neuroscience Department, The Scripps Research Institute, La Jolla, CA, USA.); Zakhari S ( Office of Science, Distilled Spirits Council of the United States, Washington, DC, USA.); Mayfield RD ( Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, 2500 Speedway, Austin, TX 78712, USA.); Harris RA ( Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, 2500 Speedway, Austin, TX 78712, USA. Electronic address: harris@austin.utexas.edu.) |
| Abstract | This review summarizes the proceedings of a symposium presented at the 'Alcoholism and Stress: A Framework for Future Treatment Strategies' conference held in Volterra, Italy on May 6-9, 2014. The overall goal of the symposium titled 'Applying the New Genomics to Alcohol Dependence', chaired by Dr. Adron Harris, was to highlight recent genomic discoveries and applications for profiling alcohol use disorder (AUD). Dr. Sean Farris discussed the gene expression networks related to lifetime consumption of alcohol within human prefrontal cortex. Dr. Andrzej Pietrzykowski presented the effects of alcohol on microRNAs in humans and animal models. Alcohol-induced alterations in the synaptic transcriptome were discussed by Dr. Michael Miles. Dr. Pietro Sanna examined methods to probe the gene regulatory networks that drive excessive alcohol drinking, and Dr. Samir Zakhari served as a panel discussant and summarized the proceedings. Collectively, the presentations emphasized the power of integrating multiple levels of genetics and transcriptomics with convergent biological processes and phenotypic behaviors to determine causal factors of AUD. The combined use of diverse data types demonstrates how unique approaches and applications can help categorize genetic complexities into relevant biological networks using a systems-level model of disease. |
| File Format | HTM / HTML |
| ISSN | 07418329 |
| Issue Number | 8 |
| Volume Number | 49 |
| e-ISSN | 18736823 |
| Journal | Alcohol |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-12-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Substance-Related Disorders Alcoholism Genetics Epigenesis, Genetic Gene Expression Regulation Micrornas Transcriptome Animals Gene Expression Profiling Gene Regulatory Networks Genomics Humans Sequence Analysis, Rna Journal Article Research Support, N.i.h., Extramural Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neurology Medicine Behavioral Neuroscience Health (social science) Biochemistry Toxicology |
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