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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Toledo-Corral, Claudia M. Banner, Lisa R. |
| Description | Country affiliation: United States Author Affiliation: Toledo-Corral CM ( Department of Biology, California State University, Northridge, 91330-8330, USA.) |
| Abstract | Peripheral neuropathy is a common complication of diabetes mediated by alterations of growth factors. Members of the neuropoietic cytokine family, which include IL-6, LIF, and CNTF among others, have been shown to be important regulators of peripheral nerves and the muscles that they innervate. To investigate their potential role in diabetic nerve and muscle, we studied the expression of the shared receptor subunits, LIFR and gp130 in a mouse model of streptozotocin (STZ)-induced diabetes. The results of Western blotting and densitometric analysis showed that both LIFR and gp130 protein expression were increased in diabetic sciatic nerve compared to control mice at early time points following STZ injection. In diabetic gastrocnemius muscle, LIFR and gp130 were increased from 3 days to 24 weeks following STZ injection. In contrast, both LIFR and gp130 protein expression were decreased in diabetic soleus muscle at 3-days post-injection. Our results suggest that hyperglycemia results in changes to nerve and muscle soon after the onset of diabetes and that cytokines may play a role in this process. |
| File Format | HTM / HTML |
| ISSN | 00651281 |
| Issue Number | 2 |
| Volume Number | 114 |
| e-ISSN | 16180372 |
| Journal | Acta Histochemica |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-02-01 |
| Publisher Place | Germany |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Histocytochemistry Cytokine Receptor Gp130 Metabolism Diabetes Mellitus, Experimental Leukemia Inhibitory Factor Receptor Alpha Subunit Muscle, Skeletal Sciatic Nerve Age Factors Animals Blood Glucose Blotting, Western Genetics Female Male Mice Mice, Inbred C57bl Streptozocin Up-regulation Journal Article Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Histology |
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