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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Narita, Diana Seclaman, Edward Ursoniu, Sorin Anghel, Andrei |
| Description | Country affiliation: Romania Author Affiliation: Narita D ( Department of Biochemistry, University of Medicine and Pharmacy 'Victor Babes', Timisoara, Romania. diana_narita@yahoo.com) |
| Abstract | ADAMs (a desintegrin and metalloprotease) are transmembrane glycoproteins involved in cell growth, differentiation, motility, and respectively, tumor growth and progression. Our aim was to evaluate ADAM12 spliced variants (ADAM12L - long membrane-bound and ADAM12S - secreted-short variant) and ADAM17 genes expression in breast cancers and to correlate their level of expression with clinical and pathological characteristics. Expression of ADAMs was analyzed using quantitative reverse-transcription polymerase chain reaction in laser-capture microdissected specimens of breast cancers and corresponding non-neoplastic breast tissues from 92 patients. The proteins' expression was confirmed by immunohistochemistry. Significantly elevated amounts of ADAM12L, ADAM12S and ADAM17 transcripts were found in malignant breast cells compared with normal breast tissue and both ADAMs proteins showed moderate to strong immunoexpression in tumor cells and peritumoral fibroblasts. ADAM12L and ADAM12S expressions were correlated with age, younger patients having higher expression of ADAM12L and ADAM12S; ductal cancers had higher expression of ADAM12L compared with lobular types, whereas ADAM12S was higher expressed in lobular cancers; higher expressions were found for both ADAM12 and ADAM17 in HER2/neu positive and highly proliferative cancers. High-grade cancers showed significantly increased expression of ADAM17. Our study on laser-capture microdissected specimens confers motivation for future work on development of ADAM-selective inhibitors for treatment of breast cancers. |
| File Format | HTM / HTML |
| ISSN | 00651281 |
| Issue Number | 2 |
| Volume Number | 114 |
| e-ISSN | 16180372 |
| Journal | Acta Histochemica |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-02-01 |
| Publisher Place | Germany |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Histocytochemistry Adam Proteins Metabolism Breast Neoplasms Carcinoma, Ductal, Breast Carcinoma, Lobular Membrane Proteins Genetics Adult Aged Aged, 80 And Over Alternative Splicing Pathology Female Gene Expression Gene Expression Regulation, Neoplastic Humans Isoenzymes Laser Capture Microdissection Middle Aged Neoplasm Staging Tumor Burden Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Histology |
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