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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kulkarni, Aditya Alpadi, Kannan Sirupangi, Tirupataiah Peters, Christopher |
| Description | Country affiliation: United States Author Affiliation: Kulkarni A ( Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, 77030, USA.) |
| Abstract | The convergence of the antagonistic reactions of membrane fusion and fission at the hemifusion/hemifission intermediate has generated a captivating enigma of whether Soluble N-ethylmaleimide sensitive factor Attachment Protein Receptor (SNAREs) and dynamin have unusual counter-functions in fission and fusion, respectively. SNARE-mediated fusion and dynamin-driven fission are fundamental membrane flux reactions known to occur during ubiquitous cellular communication events such as exocytosis, endocytosis and vesicle transport. Here we demonstrate the influence of the dynamin homolog Vps1 (Vacuolar protein sorting 1) on lipid mixing and content mixing properties of yeast vacuoles, and on the incorporation of SNAREs into fusogenic complexes. We propose a novel concept that Vps1, through its oligomerization and SNARE domain binding, promotes the hemifusion-content mixing transition in yeast vacuole fusion by increasing the number of trans-SNAREs. |
| File Format | HTM / HTML |
| ISSN | 13989219 |
| e-ISSN | 16000854 |
| DOI | 10.1111/tra.12156 |
| Journal | Traffic |
| Issue Number | 5 |
| Volume Number | 15 |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2014-05-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Discipline Physiology Dynamins Metabolism Intracellular Membranes Physiology Membrane Fusion Fungal Proteins Lipid Bilayers Protein Transport Snare Proteins Vacuoles Yeasts Research Support, N.i.h., Extramural |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Genetics Structural Biology Molecular Biology Biochemistry |
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