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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Tousson, Ehab |
| Description | Country affiliation: Egypt Author Affiliation: Tousson E ( Department of Zoology, Faculty of Science, Tanta University, Tanta, Egypt toussonehab@yahoo.com.) |
| Abstract | Boldenone (BOL) is a derivative of the testosterone that has dual effects on humans, both directly and indirectly; directly as injection to build muscles and indirectly as through consuming meat of animals that where treated with BOL. However, the action of these steroids on different body organs structures is still unclear; therefore, the aim of the present study was to investigate the effect of the intramuscular injection of BOL undecylenate on the different organ structures. A total of 10 adult New Zealand rabbits were divided into two main groups, the first group was the control group, which includes animals that were injected intramuscularly with olive oil and the second group included animals that received two intramuscular injections of 5 mg/kg body weight BOL dissected after 6 weeks. Our results showed that intramuscular injection of rabbits with BOL showed hypertrophy in both skeletal and cardiac muscles, disturbances of the hepatocytes radially arranged cords with multifocal hepatocellular vacuolations in the liver, glomerulus mass reduction with multifocal glomerular injury in the kidney, disturbances of the cycle of spermatogenesis in the testes. In conclusion, using BOL, while preparing for a young bodybuilding contest, may cause an alteration in the histological structure of most of the body organs; these findings suggested that especially young people who misuse anablic androgenic steroids should be careful if they want to use such steroids to enhance their strength and endurance. |
| File Format | HTM / HTML |
| ISSN | 07482337 |
| Issue Number | 2 |
| Volume Number | 32 |
| e-ISSN | 14770393 |
| Journal | Toxicology and Industrial Health |
| Language | English |
| Publisher | Sage Publications |
| Publisher Date | 2016-02-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Occupational Medicine Discipline Toxicology Anabolic Agents Adverse Effects Testosterone Analogs & Derivatives Administration & Dosage Animals Dose-response Relationship, Drug Heart Drug Effects Hepatocytes Pathology Intestine, Small Kidney Liver Male Muscle, Skeletal Myocardium Rabbits Spermatogenesis Testis Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology |
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