NDLI: Signet-ring stromal tumor of the ovary: report of a case and review of the literature.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hardisson, David Regojo, Rita M. Mariño-Enríquez, Adrián Martínez-García, Mayte
Description	Country affiliation: Spain Author Affiliation: Hardisson D ( Department of Pathology, University Hospital La Paz, Autonomous University of Madrid, Madrid, Spain. dhardisson.hulp@salud.madrid.org)
Abstract	Signet-ring stromal tumor of the ovary is extremely rare, with only ten cases reported in the literature. We report on a case of signet-ring stromal tumor of the left ovary in a 54-year-old woman who presented with abdominal discomfort. Histologically, the tumor was composed of an admixture of spindle and round cells which contained a large cytoplasmic vacuole which displaced the nucleus, creating a signet-ring appearance. Numerous cells showed intracytoplasmic hyaline globules. Immunohistochemically, the tumor cells showed positivity for vimentin, actin, inhibin, and calretinin, thus confirming the ovarian stromal origin of the neoplasm. The patient remains free of disease one year and 9 months after surgery. Signet-ring tumor of the ovary is a rare variant of benign ovarian stromal neoplasm and should be distinguished from metastatic mucin-secreting signet-ring adenocarcinoma.
File Format	HTM / HTML
ISSN	12194956
Issue Number	3
Volume Number	14
e-ISSN	15322807
Journal	Pathology & Oncology Research
Language	English
Publisher	Springer
Publisher Date	2008-09-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Oncology Ovarian Neoplasms Diagnosis Pathology Stromal Cells Actins Metabolism Tumor Markers, Biological Calbindin 2 Carcinoma, Signet Ring Cell Diagnosis, Differential Female Humans Inhibins Middle Aged S100 Calcium Binding Protein G Vimentin Case Reports Journal Article Review
Content Type	Text
Resource Type	Case study Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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