NDLI: Osteopontin expression correlates with angiogenesis and survival in malignant astrocytoma.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Matusan-Ilijas, Koviljka Behrem, Senija Jonjic, Nives Zarkovic, Kamelija Lucin, Ksenija
Description	Country affiliation: Croatia Author Affiliation: Matusan-Ilijas K ( Department of Pathology, Rijeka University School of Medicine, Rijeka, Croatia. kmatusan@yahoo.com)
Abstract	Osteopontin (OPN) is a phosphorylated glycoprotein with diverse functions including angiogenesis, cancer development, invasion and metastasis. The aim of the study was to analyze the expression of OPN in human astrocytomas and to correlate it with angiogenesis and patients' outcome. Seventy-six human astrocytomas including eight pilocytic astrocytomas (grade I), 10 diffuse astrocytomas (grade II), 8 anaplastic astrocytomas (grade III) and 50 glioblastomas (grade IV) were immunohistochemically stained for OPN protein. The distribution of OPN staining (cytoplasmic and/or interstitial) was assessed and compared to microvessel number and patients' survival. In normal brain tissue some glial and neuronal cells showed weak cytoplasmic staining, while interstitium was negative. Astrocytomas were heterogeneous regarding the OPN expression. High cytoplasmic OPN expression in glioblastomas was associated with poor patients' survival (p = 0.012). Also, we found the association of interstitial OPN expression and angiogenesis (p = 0.033), i.e. the number of newly formed blood vessels was higher in tumors showing high interstitial OPN expression. Our results indicate the overexpression of OPN protein in astrocytoma cells and suggest the role of OPN in astrocytoma progression and angiogenesis.
File Format	HTM / HTML
ISSN	12194956
Issue Number	3
Volume Number	14
e-ISSN	15322807
Journal	Pathology & Oncology Research
Language	English
Publisher	Springer
Publisher Date	2008-09-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Oncology Astrocytoma Blood Supply Metabolism Tumor Markers, Biological Brain Neoplasms Neovascularization, Pathologic Osteopontin Mortality Brain Pathology Disease Progression Humans Kaplan-meier Estimate Prognosis Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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