NDLI: Clinical significance of ephrin (eph)-A1, -A2, -a4, -a5 and -a7 receptors in pancreatic ductal adenocarcinoma.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Giaginis, Constantinos Tsourouflis, Gerasimos Zizi-Serbetzoglou, Adamantia Kouraklis, Gregorios Chatzopoulou, Elli Dimakopoulou, Konstantina Theocharis, Stamatios E.
Description	Country affiliation: Greece Author Affiliation: Giaginis C ( Department of Forensic Medicine and Toxicology, Medical School, University of Athens, 75 Mikras Asias str., Athens, 11527, Greece.)
Abstract	Ephrin (Eph) receptors have been reported to be frequently overexpressed in a wide variety of cancer types, being associated with tumor growth, invasion, metastasis and angiogenesis. The aim of the present study was to evaluate the clinical significance of Eph-A1, -A2, -A4, -A5 and -A7 expression in pancreatic ductal adenocarcinoma. Eph-A1, -A2, -A4, -A5 and -A7 expression and staining intensity were assessed immunohistochemically in tumoral samples of 67 pancreatic adenocarcinoma patients and were statistically analyzed in relation to clinicopathological characteristics, tumor proliferative capacity and patients' survival. Eph receptors were abundantly expressed in pancreatic ductal adenocarcinoma cases examined. Eph-A1 staining intensity was significantly associated with tumor size (pT, p = 0.008) and tumor histopathological stage (pStage, p = 0.012). Eph-A2 expression was significantly associated with patients' age (p = 0.007), while Eph-A4 and Eph-A5 with tumor proliferative capacity (p = 0.019 and p = 0.011, respectively). Pancreatic adenocarcinoma patients with moderate/intense Eph-A5 or Eph-A7 staining presented significantly shorter survival times compared to those with negative/mild one (log-rank test, p = 0.024 and p = 0.009, respectively). Multivariate analysis identified Eph-A5 and Eph-A7 staining intensity as independent prognostic factors (p = 0.048 and p = 0.004, respectively). In conclusion, the present study revealed that Eph receptors were associated with pancreatic cancer characteristics, supporting evidence for their potential clinical application in management and prognosis of pancreatic adenocarcinoma patients.
File Format	HTM / HTML
ISSN	12194956
Issue Number	2
Volume Number	16
e-ISSN	15322807
Journal	Pathology & Oncology Research
Language	English
Publisher	Springer
Publisher Date	2010-06-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Oncology Tumor Markers, Biological Analysis Carcinoma, Pancreatic Ductal Metabolism Pancreatic Neoplasms Receptors, Eph Family Biosynthesis Aged Mortality Pathology Female Humans Immunohistochemistry Kaplan-meier Estimate Male Neoplasm Staging Prognosis Receptor, Epha1 Receptor, Epha2 Receptor, Epha4 Receptor, Epha5 Receptor, Epha7 Journal Article
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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