NDLI: Proximal-type epithelioid sarcoma in the groin presenting as a diagnostic dilemma.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mannan, Abul Ala Syed Rifat Rifaat, Amre A. Kahvic, Mirza Kapila, Kusum Mallik, Mrinmay Grover, Vinod Kumar Bharati, Chandramouli Perry, Arie
Description	Country affiliation: Kuwait Author Affiliation: Mannan AA ( Department of Pathology, Al Jahra Hospital, Jahra, Kuwait. mannanrifat@rediffmail.com)
Abstract	Epithelioid sarcoma is an uncommon soft-tissue sarcoma typically presenting as a subcutaneous or deep dermal mass in the distal extremities of young adults. Lately, a 'proximal' subtype has been described, which occurs in the pelvic and genital areas of somewhat older individuals and tends to behave more aggressively than the conventional subtype. The correct diagnosis of this subtype is essential, since this tumor can be easily mistaken for other malignant tumors that exhibit epithelioid morphology. We report a case of proximal-type epithelioid sarcoma that presented as an inguinal mass in a 47-year-old man. Histologically, the tumor consisted of diffuse sheets of epithelioid cells with scattered rhabdoid morphology. By immunohistochemistry, the neoplastic cells expressed cytokeratin, epithelial membrane antigen, vimentin, CD34, CD99 and showed complete loss of nuclear INI1 protein expression. Fluorescence in situ hybridization was considered borderline for 22q deletion. We present this case to emphasize the importance of diagnosing this uncommon tumor and the role of INI1 immunohistochemistry in establishing the diagnosis.
File Format	HTM / HTML
ISSN	12194956
Issue Number	2
Volume Number	16
e-ISSN	15322807
Journal	Pathology & Oncology Research
Language	English
Publisher	Springer
Publisher Date	2010-06-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Oncology Pelvic Neoplasms Pathology Sarcoma Soft Tissue Neoplasms Chromosomal Proteins, Non-histone Biosynthesis Chromosomes, Human, Pair 22 Dna-binding Proteins Humans Immunohistochemistry In Situ Hybridization, Fluorescence Male Middle Aged Genetics Metabolism Transcription Factors Case Reports Journal Article
Content Type	Text
Resource Type	Case study Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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