NDLI: Increased expression of prohibitin and its relationship with poor prognosis in esophageal squamous cell carcinoma.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ren, Hong-Zheng Wang, Jin-Sheng Wang, Peng Pan, Guo-qing Wen, Ji-Fang Fu, Hua Shan, Xu-zheng
Description	Country affiliation: China Author Affiliation: Ren HZ ( Department of Pathology, Xiangya Basic Medical College, Central South University, Changsha, China.)
Abstract	Prohibitin, a potential tumor suppressor, has been shown to be an anti- proliferative protein, a regulator of cell-cycle progression and in apoptosis. Recently, it was found to be over-expressed in breast cancer and gastric cancer, and it has been suggested as a biomarker in those diseases. To clarify the role and the prognostic significance of prohibitin expression in esophageal squamous cell carcinoma (ESCC), we analyzed the expression in ESCC and their corresponding nonneoplastic epithelia tissues by immunohistochemistry(IHC), Western blotting and real-time quantitative reverse transcription polymerase chain reaction(QRT-PCR).The relationship between prohibitin expression and clinicopathological variables was examined by statistical analysis. The findings suggested the up-regulation of prohibitin play an important role in the carcinogenesis of ESCC. The over-expression of prihibitin was significantly correlated with the depth of tumor, lymph node metastasis, distant metastasis, lymphatic invasion and vascular invasion of ESCC. These results suggested that prohibitin(+), lymph node metastasis and distant metastasis could be the independent risk factors for worse prognosis in ESCC patients.
File Format	HTM / HTML
ISSN	12194956
Issue Number	4
Volume Number	16
e-ISSN	15322807
Journal	Pathology & Oncology Research
Language	English
Publisher	Springer
Publisher Date	2010-12-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Oncology Carcinoma, Squamous Cell Metabolism Esophageal Neoplasms Repressor Proteins Biosynthesis Adult Aged Analysis Of Variance Blotting, Western Genetics Pathology Chi-square Distribution Female Humans Immunohistochemistry Male Middle Aged Polymerase Chain Reaction Prognosis Proportional Hazards Models Rna, Messenger Survival Analysis Tissue Array Analysis Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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