NDLI: Prognostic significance of p53 protein expression in early gastric cancer.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Gonçalves, Andrea Rodrigues Carneiro, Antonio Jose Vasconcellos Martins, Ivanir de Faria, Paulo Antonio Silvestre Ferreira, Maria Aparecida de Mello, Eduardo Linhares Riello Fogaça, Homero Soares Elia, Celeste Carvalho Siqueira de Souza, Heitor Siffert Pereira
Description	Country affiliation: Brazil Author Affiliation: Gonçalves AR ( Departamento de Clínica Médica, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.)
Abstract	Mutations of the p53 tumor suppressor gene have been associated with abnormalities in cell cycle regulation, DNA repair and synthesis, apoptosis, and it has been implicated in the prognosis of advanced gastric cancer. The aim of this study was to evaluate the occurrence of p53 gene mutation and its possible prognostic implications in early gastric cancer. In a retrospective study, we studied 80 patients with early gastric cancer treated surgically between 1982 and 2001. Mutation of p53 gene was investigated in surgical gastric specimens by immunohistochemistry, and results were analyzed in relation to gender, age, macroscopic appearance, size and location of tumor, presence of lymph nodes, Lauren's histological type, degree of differentiation, and the 5-year survival. The expression of p53 was more frequent among the intestinal type (p = 0.003), the differentiated (p = 0.007), and the macroscopically elevated tumors (p = 0.038). Nevertheless, the isolated expression of p53 was not associated with the 5-year survival, or with the frequency of lymph node involvement. The degree of differentiation was detected as an independent factor related to the outcome of patients (0.044). Significantly shorter survival time was found in p53-negative compared with p53-positive patients, when considering the degree of differentiation of tumors, as assessed by Cox regression analysis (0.049). The association of p53 with the intestinal type, the degree of differentiation and morphological characteristics, may reflect the involvement of chronic inflammatory process underlying early gastric cancer. In this population sample, the expression of p53 alone has no prognostic value for early gastric cancer. However, the significant difference in p53 expression between subgroups of degree of differentiation of tumors can influence post-operative outcome of patients and may be related to possible distinct etiopathogenic subtypes.
File Format	HTM / HTML
ISSN	12194956
Issue Number	2
Volume Number	17
e-ISSN	15322807
Journal	Pathology & Oncology Research
Language	English
Publisher	Springer
Publisher Date	2011-06-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Oncology Adenocarcinoma Metabolism Tumor Markers, Biological Analysis Stomach Neoplasms Tumor Suppressor Protein P53 Biosynthesis Mortality Pathology Cell Differentiation Female Humans Immunohistochemistry Kaplan-meier Estimate Male Middle Aged Prognosis Proportional Hazards Models Retrospective Studies Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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