NDLI: Multicentric Castleman's disease: a challenging diagnosis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Muzes, Györgyi Sipos, Ferenc Csomor, Judit Sréter, Lídia
Description	Country affiliation: Hungary Author Affiliation: Muzes G ( 2nd Department of Medicine, Semmelweis University, 1088 Budapest, Szentkirályi u. 46., Hungary. muzes.gyorgyi@med.semmelweis-univ.hu)
Abstract	Multicentric Castleman's disease (MCD) is a sytemic disorder with flares of non-specific symptoms suggestive of a chronic inflammatory syndrome. It is typically accompanied by generalized lymphadenopathy and multiorgan involvement. Histologically, two main variants of Castleman's disease exist, the hyalin vascular type and the plasma cell variant. Upon localization unicentric (localized), and multicentric (diffuse, systemic) subtypes can be distinguished with more different disease outcomes. Patients often exhibit acute phase reactions and several autoimmune phenomena, and are at high risk for developing malignancies. Both the idiopathic and the HHV-8-driven infectious forms of MCD represent distinct disease entities with a less favorable prognosis. The induction of human IL-6 excess via yet unknown upstream mechanisms, and overexpression of viral IL-6 by HHV-8 can pivotally influence MCD biology. Based on the role of IL-6 in pathogenesis, MCD is also designated as IL-6 lymphadenopathy. To date there are no direct therapeutic evidences, but having been translated to daily practice the main regulatory factors may serve as promising therapeutic targets.
File Format	HTM / HTML
ISSN	12194956
Issue Number	3
Journal	Pathology & Oncology Research
Volume Number	19
e-ISSN	15322807
Language	English
Publisher	Springer
Publisher Date	2013-07-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Oncology Giant Lymph Node Hyperplasia Diagnosis Classification Humans Journal Article Review
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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