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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Rutz, Sascha Wang, Xiaoting Ouyang, Wenjun |
| Description | Country affiliation: United States Author Affiliation: Rutz S ( Department of Immunology, Genentech, South San Francisco, California 94080, USA.); Wang X ( Department of Immunology, Genentech, South San Francisco, California 94080, USA.); Ouyang W ( Department of Immunology, Genentech, South San Francisco, California 94080, USA.) |
| Abstract | The interleukin-20 (IL-20) subfamily of cytokines comprises IL-19, IL-20, IL-22, IL-24 and IL-26. These cytokines are all members of the larger IL-10 family, but have been grouped together to form the IL-20 subfamily based on their usage of common receptor subunits and similarities in their target-cell profiles and biological functions. Members of the IL-20 subfamily facilitate the communication between leukocytes and epithelial cells, thereby enhancing innate defence mechanisms and tissue repair processes at epithelial surfaces. In this Review, we describe the cellular sources and targets of the IL-20 subfamily cytokines, and we detail how their expression is regulated. Much of our understanding of the unique biology of this group of cytokines is still based on IL-22, which is the most studied member of the IL-20 subfamily. Nevertheless, we attempt a broader discussion of the emerging functions of IL-20 subfamily cytokines in host defence, inflammatory diseases, cancer and metabolism. |
| File Format | HTM / HTML |
| ISSN | 14741733 |
| Issue Number | 12 |
| Volume Number | 14 |
| e-ISSN | 14741741 |
| Journal | Nature Reviews Immunology |
| Language | English |
| Publisher | Nature Publishing Group |
| Publisher Date | 2014-12-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Immunology Immunity, Innate Immunology Inflammation Interleukins Receptors, Interleukin Animals Cell Communication Epithelial Cells Cytology Homeostasis Humans Leukocytes Models, Molecular Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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