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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Moaddab, Mahsa Hyland, Brian I. Brown, Colin H. |
| Description | Country affiliation: New Zealand Author Affiliation: Moaddab M ( Centre for Neuroendocrinology, University of Otago, Dunedin 9054, New Zealand); Hyland BI ( Department of Physiology, University of Otago, Dunedin 9054, New Zealand.); Brown CH ( Centre for Neuroendocrinology, University of Otago, Dunedin 9054, New Zealand) |
| Abstract | Oxytocin modulates reward-related behaviors. The nucleus accumbens shell (NAcSh) is a major relay in the brain reward pathway and expresses oxytocin receptors, but the effects of oxytocin on the activity of NAcSh neurons in vivo are unknown. Hence, we used in vivo extracellular recording to show that intracerebroventricular (ICV) oxytocin administration (0.2µg) robustly increased medial NAcSh neuron mean firing rate; this increase was almost exclusively evident in slow-firing neurons and was not associated with any change in firing pattern. To determine whether oxytocin excitation of medial NAcSh neurons is modulated by drugs that impact the brain reward pathway, we next tested the effects of ICV oxytocin following repeated morphine treatment. In morphine-treated rats, ICV oxytocin did not affect the mean firing rate of medial NAcSh neurons. Taken together, these results show that oxytocin excites medial NAcSh neurons but does not do so after repeated morphine. This could be an important factor in oxytocin modulation of reward-related behaviors, such as drug addiction. |
| File Format | HTM / HTML |
| ISSN | 10447431 |
| Volume Number | 68 |
| e-ISSN | 10959327 |
| Journal | Molecular and Cellular Neuroscience |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-09-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Cell Biology Discipline Molecular Biology Discipline Neurology Action Potentials Drug Effects Neurons Nucleus Accumbens Cytology Oxytocics Pharmacology Oxytocin Analgesics, Opioid Analysis Of Variance Animals Dose-response Relationship, Drug Male Morphine Rats Rats, Wistar Time Factors Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Molecular Biology Cellular and Molecular Neuroscience |
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