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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Smith, Andrew G. Raven, Emma Lloyd Chernova, Tatyana |
| Description | Country affiliation: United kingdom Author Affiliation: Smith AG ( MRC Toxicology Unit, Hodgkin Building, Lancaster Road, Leicester LE1 9HN, United Kingdom.) |
| Abstract | The involvement of the metallic element iron in various biological systems is well known. In many cases, iron is employed in the form of a heme group and the family of proteins and catalytic enzymes that contain heme is well documented (e.g. the globins, cytochromes, and P450s). For many of these proteins, there is a great deal of information available in terms of structures, catalytic mechanism and function. This has led to a collective view that the main role of heme in biological systems is as a prosthetic group, binding to individual proteins and thereby conferring upon them particular functional properties. It is now becoming clear that this description represents only a part of a much more complex involvement of heme in biology and that other roles, for example in regulation and sensing, have been overlooked. This mini-review focuses on one such emerging role: the regulatory role of heme in neurons. |
| File Format | HTM / HTML |
| ISSN | 17565901 |
| Issue Number | 10 |
| Volume Number | 3 |
| e-ISSN | 1756591X |
| Journal | Metallomics |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Publisher Date | 2011-10-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry Heme Metabolism Neurons Animals Analysis Genetics Humans Iron Models, Molecular Cytology Journal Article Research Support, Non-u.s. Gov't Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Medicine Metals and Alloys Biochemistry Biomaterials Biophysics |
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