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Role of metal ions in aggregation of intrinsically disordered proteins in neurodegenerative diseases.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Breydo, Leonid Uversky, Vladimir N.
Description	Country affiliation: United States Author Affiliation: Breydo L ( Department of Molecular Medicine, College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd, MDC07, Tampa, Florida 33612, USA. lbreydo@health.usf.edu)
Abstract	Neurodegenerative diseases constitute a set of pathological conditions originating from the slow, irreversible, and systematic cell loss within the various regions of the brain and/or the spinal cord. Depending on the affected region, the outcomes of the neurodegeneration are very broad and diverse, ranging from the problems with movements to dementia. Some neurodegenerative diseases are associated with protein misfolding and aggregation. Many proteins that misfold in human neurodegenerative diseases are intrinsically disordered; i.e., they lack a stable tertiary and/or secondary structure under physiological conditions in vitro. These intrinsically disordered proteins (IDPs) functionally complement ordered proteins, being typically involved in regulation and signaling. There is accumulating evidence that altered metal homeostasis may be related to the progression of neurodegenerative diseases. This review examines the effects of metal ion binding on the aggregation pathways of IDPs found in neurodegenerative diseases.
File Format	HTM / HTML
ISSN	17565901
Issue Number	11
Volume Number	3
e-ISSN	1756591X
Journal	Metallomics
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2011-11-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Biochemistry Ions Chemistry Metals Neurodegenerative Diseases Metabolism Protein Conformation Protein Structure, Secondary Protein Structure, Tertiary Proteins Amino Acid Sequence Humans Molecular Structure Prion Diseases Prions Protein Folding Genetics Journal Article Research Support, Non-u.s. Gov't Review
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Metals and Alloys Biochemistry Biomaterials Biophysics

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