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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Chung, In-Young Bae, Hee-Won Jang, Hye-Jung Kim, Bi-o Cho, You-Hee |
| Description | Author Affiliation: Chung IY ( Department of Pharmacy, College of Pharmacy, CHA University, Gyeonggi-do, 463-840, Republic of Korea.) |
| Abstract | Temperate siphophages (MP29, MP42, and MP48) were isolated from the culture supernatant of clinical Pseudomonas aeruginosa isolates. The complete nucleotide sequences and annotation of the phage genomes revealed the overall synteny to the known temperate P. aeruginosa phages such as MP22, D3112, and DMS3. Genome-level sequence analysis showed the conservation of both ends of the linear genome and the divergence at the previously identified dissimilarity regions (R1 to R9). Protein sequence alignment of the c repressor (ORF1) of each phage enabled us to divide the six phages into two groups: D3112 group (D3112, MP29, MP42, and MP48) and MP22 group (MP22 and DMS3). Superinfection exclusion was observed between the phages belonging to the same group, which was mediated by the specific interaction between the c repressor and the cognate operator. Based on these, we suggest that the temperate siphophages prevalent in the clinical strains of P. aeruginosa represent at least two distinct heteroimmunity groups. |
| File Format | HTM / HTML |
| ISSN | 12258873 |
| Issue Number | 6 |
| Journal | Journal of Microbiology |
| Volume Number | 52 |
| e-ISSN | 19763794 |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2014-06-01 |
| Publisher Place | Korea (South) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Microbiology Pseudomonas Phages Immunology Pseudomonas Aeruginosa Genetics Superinfection Virology Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Microbiology Applied Microbiology and Biotechnology |
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