NDLI: Thiopurine S-methyltransferase genotype and the use of thiopurines in paediatric inflammatory bowel disease Greek patients.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Gazouli, M. Pachoula, I. Panayotou, I. Mantzaris, G. Syriopoulou, V. P. Goutas, N. Vlachodimitropoulos, D. Anagnou, N. P. Roma-Giannikou, E.
Spatial Coverage	Greece
Description	Country affiliation: Greece Author Affiliation: Gazouli M ( Department of Biology, School of Medicine, University of Athens, Athens, Greece.)
Abstract	BACKGROUND AND OBJECTIVE: Azathioprine (AZA) and 6-mercaptopurine (6MP) are used in the treatment of paediatric inflammatory bowel disease (IBD). Genetic variations in thiopurine S-methyltranfarase (TPMT) gene have been correlated with enzyme activity and with the occurrence of adverse events to AZA and 6MP. The aim of the present study was to investigate the frequency of the functional TPMT polymorphisms and their association with the occurrence of adverse events during azathioprine therapy in a paediatric IBD cohort. METHODS: Ninety-seven thiopurine-treated paediatric IBD patients (41.24% boys and 58.76% girls) with a mean age 11.25 years (range 3-16), were assessed for TPMT polymorphisms and adverse events. RESULTS: Of the 97 patients enrolled in the study, 18 (18.56%) were heterozygous mutated; two (2.06%) were homozygous for a mutated TPMT gene. Ten patients (10.31%) developed adverse effects, and four of them (40%) had one of the variant alleles. CONCLUSIONS: In this small cohort of subjects, no association was found between TPMT polymorphisms and the occurrence of thiopurines-related adverse events.
File Format	HTM / HTML
ISSN	02694727
Issue Number	1
Volume Number	35
e-ISSN	13652710
Journal	Journal of Clinical Pharmacy and Therapeutics
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2010-02-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Therapeutics Discipline Pharmacology 6-mercaptopurine Adverse Effects Azathioprine Genetic Association Studies Immunosuppressive Agents Inflammatory Bowel Diseases Drug Therapy Methyltransferases Genetics Polymorphism, Genetic Therapeutic Use Adolescent Alleles Child Child, Preschool Female Greece Heterozygote Homozygote Humans Blood Male Polymorphism, Restriction Fragment Length Journal Article
Content Type	Text
Resource Type	Article
Subject	Pharmacology Pharmacology (medical)

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