NDLI: Impact of ALLHAT publication on antihypertensive prescribing patterns in Regione Emilia-Romagna, Italy.

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Impact of ALLHAT publication on antihypertensive prescribing patterns in Regione Emilia-Romagna, Italy.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Maio, V. Gagne, J. J.
Spatial Coverage	Italy
Description	Country affiliation: United States Author Affiliation: Maio V ( Department of Health Policy, Jefferson Medical College, Philadelphia, PA 19107, USA. vittorio.maio@jefferson.edu)
Abstract	BACKGROUND AND OBJECTIVE: Studies from the US and Canada observed changes in antihypertensive prescribing patterns in accordance with Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) study findings immediately after the study's publication, but little is known about the impact of ALLHAT in Italy. The objective of this study was to examine antihypertensive prescribing patterns in Regione Emilia-Romagna (RER), Italy, following the publication of the ALLHAT main results. METHODS: We conducted a time series analysis using automated pharmacy data of approximately 4 million RER residents between 1 January 2000 and 31 December 2003. We computed monthly relative percentages of prescriptions for all antihypertensive medications and separately for all new antihypertensives defined as no recorded antihypertensive use in the previous year. A stepwise auto-regressive forecasting model based on data prior to the ALLHAT publication was used to estimate predicted relative percentages for the 12 months following the ALLHAT publication. Observed and predicted values were compared. RESULTS AND DISCUSSION: Use of thiazide-type diuretics showed a general increasing trend over the study period, but the difference between the observed and predicted values reached statistical significance only for new prescriptions in October 2003 (3.71% vs. 2.32%; P = 0.0170). The relative percentage of new angiotensin-converting enzyme inhibitor and angiotensin receptor blocker (ACE/ARB) prescriptions was higher than predicted for the months May to August 2003 (P < 0.05), but no significant differences were observed for total ACE/ARB prescriptions. Modest changes in patterns of prescribing of calcium channel blockers and alpha-blockers were observed. CONCLUSION: We found little evidence that the ALLHAT study had an impact on antihypertensive prescribing patterns in RER in the year following their publication.
File Format	HTM / HTML
ISSN	02694727
Issue Number	1
Volume Number	35
e-ISSN	13652710
Journal	Journal of Clinical Pharmacy and Therapeutics
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2010-02-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Therapeutics Discipline Pharmacology Antihypertensive Agents Therapeutic Use Drug Prescriptions Statistics & Numerical Data Drug Utilization Hypertension Drug Therapy Physician's Practice Patterns Adrenergic Alpha-antagonists Contraindications Adrenergic Beta-antagonists Angiotensin Receptor Antagonists Angiotensin-converting Enzyme Inhibitors Classification Calcium Channel Blockers Coronary Disease Prevention & Control Evidence-based Medicine Humans Italy Outpatients Publishing Randomized Controlled Trials As Topic Sodium Chloride Symporter Inhibitors Time Factors Journal Article
Content Type	Text
Resource Type	Article
Subject	Pharmacology Pharmacology (medical)

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