NDLI: Oral cyclosporine A treatment is feasible after myeloablative conditioning in allogeneic hematopoietic stem cell transplantation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Nygaard, M. Hovgaard, D. Schjødt, I. M. Andersen, N. S. Vindeløv, L. Sengeløv, H.
Description	Country affiliation: Denmark Author Affiliation: Nygaard M ( Hematological department, National University Hospital Rigshospitalet, Copenhagen, Denmark.)
Abstract	WHAT IS KNOWN AND OBJECTIVE: The target level and route of administration of cyclosporine A (CsA) differ between transplantation centres. It is unclear whether oral CsA is sufficient to maintain target level of CsA. CASE SUMMARY: We retrospectively analysed data from 48 adult patients, who underwent myeloablative hematopoietic stem cell transplantation. Twenty-one patients (44%) tolerated CsA orally throughout the transplantation period without increased incidence of acute graft versus host disease(aGVHD). Low concentration of CsA in week 2 was associated with increased incidence of aGVHD. WHAT IS NEW AND CONCLUSION: Oral administration of CsA is safe, less time-consuming and economically advantageous. Close monitoring of CsA concentration is important.
File Format	HTM / HTML
ISSN	02694727
Issue Number	3
Volume Number	40
e-ISSN	13652710
Journal	Journal of Clinical Pharmacy and Therapeutics
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2015-06-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Therapeutics Discipline Pharmacology Cyclosporine Administration & Dosage Hematopoietic Stem Cell Transplantation Methods Immunosuppressive Agents Transplantation Conditioning Administration, Oral Adolescent Adult Pharmacokinetics Drug Monitoring Female Graft Vs Host Disease Epidemiology Prevention & Control Humans Incidence Male Middle Aged Retrospective Studies Young Adult Journal Article
Content Type	Text
Resource Type	Article
Subject	Pharmacology Pharmacology (medical)

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