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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Tang, Fushan Zhao, Xiaojun |
| Description | Country affiliation: China Author Affiliation: Tang F ( West China Hospital Institute for Nanobiomedical Technology and Membrane Biology, West China Hospital, Sichuan University, No. 1 Ke Yuan 4th Street, Gao Peng Road, Chengdu 610041, Sichuan, China.) |
| Abstract | The formation of colloidal suspension of a hydrophobic model compound, pyrene, with self-assembling peptide RAD16-I initially demonstrated the hydrophobic interaction between RAD16-I and hydrophobic compounds. The interaction between RAD16-I and pyrene in water was further investigated by using fluorescence spectroscopy and atomic force microscopy (AFM). It was observed that the fluorescence intensities of pyrene in aqueous RAD16-I solutions increased with the increase of RAD16-I at pyrene concentration of 0.1 microM, and the I(1)/I(3) and I(1)/I(5) ratios of the emission spectra decreased as the RAD16-I concentration increased. Fluorescence results and differences in AFM images of RAD16-I aggregates with and without pyrene suggested that pyrene preferentially resided in non-polar microenvironments of RAD16-I due to the hydrophobic interaction between RAD16-I and pyrene. The potential of RAD16-I as a carrier for hydrophobic drugs was revealed with the property of pyrene transferring from the suspensions into egg phosphatidylcholine vesicles. This study gives an insight into exploitation of self-assembling peptides for encapsulation of hydrophobic compounds. |
| File Format | HTM / HTML |
| ISSN | 09205063 |
| Issue Number | 5 |
| Volume Number | 21 |
| e-ISSN | 15685624 |
| Journal | Journal of Biomaterials Science, Polymer Edition |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2010-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biomedical Engineering Hydrophobic And Hydrophilic Interactions Oligopeptides Chemistry Peptides Phosphatidylcholines Pyrenes Fluorescence Microscopy, Atomic Force Spectrometry, Fluorescence Water Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biomaterials Biophysics Bioengineering Biomedical Engineering |
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