NDLI: Extended cardiolipin anchorage to cytochrome c: a model for protein-mitochondrial membrane binding.

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Extended cardiolipin anchorage to cytochrome c: a model for protein-mitochondrial membrane binding.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sinibaldi, Federica Howes, Barry D. Piro, Maria Cristina Polticelli, Fabio Bombelli, Cecilia Ferri, Tommaso Coletta, Massimo Smulevich, Giulietta Santucci, Roberto
Description	Country affiliation: Italy Author Affiliation: Sinibaldi F ( Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università di Roma 'Tor Vergata', Italy.)
Abstract	Two models have been proposed to explain the interaction of cytochrome c with cardiolipin (CL) vesicles. In one case, an acyl chain of the phospholipid accommodates into a hydrophobic channel of the protein located close the Asn52 residue, whereas the alternative model considers the insertion of the acyl chain in the region of the Met80-containing loop. In an attempt to clarify which proposal offers a more appropriate explanation of cytochrome c-CL binding, we have undertaken a spectroscopic and kinetic study of the wild type and the Asn52Ile mutant of iso-1-cytochrome c from yeast to investigate the interaction of cytochrome c with CL vesicles, considered here a model for the CL-containing mitochondrial membrane. Replacement of Asn52, an invariant residue located in a small helix segment of the protein, may provide data useful to gain novel information on which region of cytochrome c is involved in the binding reaction with CL vesicles. In agreement with our recent results revealing that two distinct transitions take place in the cytochrome c-CL binding reaction, data obtained here support a model in which two (instead of one, as considered so far) adjacent acyl chains of the liposome are inserted, one at each of the hydrophobic sites, into the same cytochrome c molecule to form the cytochrome c-CL complex.
File Format	HTM / HTML
ISSN	09498257
Issue Number	5
Volume Number	15
e-ISSN	14321327
Journal	JBIC Journal of Biological Inorganic Chemistry
Language	English
Publisher	Springer
Publisher Date	2010-06-01
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Biochemistry Cardiolipins Chemistry Cytochromes c Mitochondrial Membranes Binding Sites Biosynthesis Isolation & Purification Kinetics Models, Molecular Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Biochemistry Inorganic Chemistry

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Extended cardiolipin anchorage to cytochrome c: a model for protein–mitochondrial membrane binding

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