NDLI: Metal ion determinants of conantokin dimerization as revealed in the X-ray crystallographic structure of the $Cd^{2+}/Mg^{2+}

Please wait, while we are loading the content...

Ruthenium versus platinum: interactions of anticancer metallodrugs with duplex oligonucleotides characterised by electrospray ionisation mass spectrometry.

EPR spectroscopy and catalase activity of manganese-bound DNA-binding protein from nutrient starved cells

Kinetic and structural studies on roles of the serine ligand and a strictly conserved tyrosine residue in nitrile hydratase

Intracellular protein binding patterns of the anticancer ruthenium drugs KP1019 and KP1339

Spectroscopic and metal-binding properties of DF3: an artificial protein able to accommodate different metal ions.

The chemical forms of mercury in human hair: a study using X-ray absorption spectroscopy.

The effect of detergents and lipids on the properties of the outer-membrane protein OmcA from Shewanella oneidensis.

Characteristic effect of an anticancer dinuclear platinum(II) complex on the higher-order structure of DNA.

Extended cardiolipin anchorage to cytochrome c: a model for protein-mitochondrial membrane binding.

Nickel superoxide dismutase: structural and functional roles of Cys2 and Cys6.

Spectroscopic and computational investigation of three Cys-to-Ser mutants of nickel superoxide dismutase: insight into the roles played by the Cys2 and Cys6 active-site residues

The metal-binding properties of the blue crab copper specific CuMT-2: a crustacean metallothionein with two cysteine triplets.

Year: 2010 Volume: 15 Issue: 4

Year: 2010 Volume: 15 Issue: 3

Year: 2010 Volume: 15 Issue: 2

Year: 2010 Volume: 15 Issue: 1

Year: 2009 Volume: 14

Year: 2008 Volume: 13

Year: 2007 Volume: 12

Year: 2005 Volume: 10

Metal ion determinants of conantokin dimerization as revealed in the X-ray crystallographic structure of the $Cd^{2+}/Mg^{2+}–con-T[K7γ]$ complex

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Cnudde, Sara E. Prorok, Mary Castellino, Francis J. Geiger, James H.
Description	Country affiliation: United States Author Affiliation: Cnudde SE ( Department of Chemistry, Michigan State University, East Lansing, 48824, USA.)
Abstract	Predatory sea snails from the Conus family produce a variety of venomous small helical peptides called conantokins that are rich in γ-carboxyglutamic acid (Gla) residues. As potent and selective antagonists of the N-methyl-d-aspartate receptor, these peptides are potential therapeutic agents for a variety of neurological conditions. The two most studied members of this family of peptides are con-G and con-T. Con-G has Gla residues at sequence positions 3, 4, 7, 10, and 14, and requires divalent cation binding to adopt a helical conformation. Although both $Ca^{2+}$ and $Mg^{2+}$ can fulfill this role, $Ca^{2+}$ induces dimerization of con-G, whereas the $Mg^{2+}-complexed$ peptide remains monomeric. A variant of con-T, con-T[K7γ] (γ is Gla), contains Gla residues at the same five positions as in con-G and behaves very similarly with respect to metal ion binding and dimerization; each peptide binds two $Ca^{2+}$ ions and two $Mg^{2+}$ ions per helix. To understand the difference in metal ion selectivity, affinity, and the dependence on $Ca^{2+}$ for dimer formation, we report here the structure of the monomeric $Cd^{2+}/Mg^{2+}–con-T[K7γ]$ complex, and, by comparison with the previously published $con-T[K7γ]/Ca^{2+}$ dimer structure, we suggest explanations for both metal ion binding site specificity and metalion-dependent dimerization.
File Format	HTM / HTML
ISSN	09498257
e-ISSN	14321327
DOI	10.1007/s00775-010-0633-2
Journal	JBIC Journal of Biological Inorganic Chemistry
Issue Number	5
Volume Number	15
Language	English
Publisher	Springer
Publisher Date	2010-06-01
Publisher Place	Germany
Access Restriction	Open
Subject Keyword	Discipline Biochemistry Cadmium Chemistry Magnesium Mollusk Venoms Organometallic Compounds Peptides Calorimetry Crystallography, X-ray Dimerization Ions Models, Molecular Molecular Structure Chemical Synthesis Isolation & Purification Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Biochemistry Inorganic Chemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Metal ion determinants of conantokin dimerization as revealed in the X-ray crystallographic structure of the Cd2+/Mg2+–con-T[K7γ] complex

Metal ion determinants of conantokin dimerization as revealed in the X-ray crystallographic structure of the Cd2+/Mg2+–con-T[K7γ] complex

Magnesium and nickel(II) furan-2,5-dicarboxylate

Crystallization and X-ray crystallographic analysis of human STAT1.

Bis[(dihydrogen $pyrophosphato-^{2}O,O`)(2,2`:6`,2``-terpyridine-^{3}N,N`,N``)copper(II)]$ 4.5-hydrate

Spatial distribution of cytoplasmic domains of the $Mg^{2+}-transporter$ MgtE, in a solution lacking $Mg^{2+},$ revealed by paramagnetic relaxation enhancement

An X-Ray Crystallographic Study of N-Methyl-3-nitro-4-(nitromethyl)-4H-chromen-2-amine

Investigations in X ray Crystallography Crystallographic studies on Glycinium Orthophosphate and Cadmium Halide Complexes of Glycine

$Poly[bis(-4-benzoyl-1-isonicotinoylthiosemicarbazide-^{2}N:S)dichloridocadmium(II)]$

Metal ion determinants of conantokin dimerization as revealed in the X-ray crystallographic structure of the $Cd^{2+}/Mg^{2+}–con-T[K7γ]$ complex

Similar Documents

Metal ion determinants of conantokin dimerization as revealed in the X-ray crystallographic structure of the Cd2+/Mg2+–con-T[K7γ] complex

Metal ion determinants of conantokin dimerization as revealed in the X-ray crystallographic structure of the Cd2+/Mg2+–con-T[K7γ] complex

Magnesium and nickel(II) furan-2,5-dicarboxyl­ate

Crystallization and X-ray crystallographic analysis of human STAT1.

Bis[(dihydrogen $pyrophosphato-^{2}O,O`)(2,2`:6`,2``-terpyridine-^{3}N,N`,N``)copper(II)]$ 4.5-hydrate

Spatial distribution of cytoplasmic domains of the $Mg^{2+}-transporter$ MgtE, in a solution lacking $Mg^{2+},$ revealed by paramagnetic relaxation enhancement

An X-Ray Crystallographic Study of N-Methyl-3-nitro-4-(nitromethyl)-4H-chromen-2-amine

Investigations in X ray Crystallography Crystallographic studies on Glycinium Orthophosphate and Cadmium Halide Complexes of Glycine

$Poly[bis(-4-benzoyl-1-isonicotinoyl­thio­semi­carbazide-^{2}N:S)dichloridocadmium(II)]$

Metal ion determinants of conantokin dimerization as revealed in the X-ray crystallographic structure of the $Cd^{2+}/Mg^{2+}–con-T[K7γ]$ complex

Magnesium and nickel(II) furan-2,5-dicarboxylate

$Poly[bis(-4-benzoyl-1-isonicotinoylthiosemicarbazide-^{2}N:S)dichloridocadmium(II)]$