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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Castaño-Vinyals, Gemma Aragonés, Nuria Pérez-Gómez, Beatriz Martín, Vicente Llorca, Javier Moreno, Victor Altzibar, Jone M. Ardanaz, Eva de Sanjosé, Sílvia Jiménez-Moleón, José Juan Tardón, Adonina Alguacil, Juan Peiró, Rosana Marcos-Gragera, Rafael Navarro, Carmen Pollán, Marina Kogevinas, Manolis |
| Description | Author Affiliation: Castaño-Vinyals G ( Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain); Aragonés N ( Environmental and Cancer Epidemiology Unit, National Center of Epidemiology, Instituto de Salud Carlos III, Madrid, Spain); Pérez-Gómez B ( Environmental and Cancer Epidemiology Unit, National Center of Epidemiology, Instituto de Salud Carlos III, Madrid, Spain); Martín V ( Universidad de León, León, Spain); Llorca J ( Universidad de Cantabria, Santander, Spain); Moreno V ( IDIBELL-Catalan Institute of Oncology, L'Hospitalet de Llobregat, Spain); Altzibar JM ( Subdirección de Salud Pública de Gipuzkoa, Donostia, Spain); Ardanaz E ( Instituto de Salud Pública de Navarra, Pamplona, Navarra); de Sanjosé S ( IDIBELL-Catalan Institute of Oncology, L'Hospitalet de Llobregat, Spain); Jiménez-Moleón JJ ( Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain); Tardón A ( Instituto Universitario de Oncología, Universidad de Oviedo, Oviedo, Asturias, Spain); Alguacil J ( Centro de Investigación en Salud y Medio Ambiente (CYSMA), Universidad de Huelva, Huelva, Spain); Peiró R ( Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana FISABIO-Salud Pública, Valencia, Spain); Marcos-Gragera R ( Epidemiology Unit and Girona Cancer Registry, Oncology Coordination Plan, Department of Health, Autonomous Government of Catalonia, Catalan Institute of Oncology, Girona Biomedical Research Institute (IdiBGi), Girona, Spain); Navarro C ( Department of Epidemiology, Murcia Regional Health Authority, Murcia, Spain); Pollán M ( Environmental and Cancer Epidemiology Unit, National Center of Epidemiology, Instituto de Salud Carlos III, Madrid, Spain); Kogevinas M ( Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain) |
| Abstract | INTRODUCTION: We present the protocol of a large population-based case-control study of 5 common tumors in Spain (MCC-Spain) that evaluates environmental exposures and genetic factors. METHODS: Between 2008-2013, 10,183 persons aged 20-85 years were enrolled in 23 hospitals and primary care centres in 12 Spanish provinces including 1,115 cases of a new diagnosis of prostate cancer, 1,750 of breast cancer, 2,171 of colorectal cancer, 492 of gastro-oesophageal cancer, 554 cases of chronic lymphocytic leukaemia (CLL) and 4,101 population-based controls matched by frequency to cases by age, sex and region of residence. Participation rates ranged from 57% (stomach cancer) to 87% (CLL cases) and from 30% to 77% in controls. Participants completed a face-to-face computerized interview on sociodemographic factors, environmental exposures, occupation, medication, lifestyle, and personal and family medical history. In addition, participants completed a self-administered food-frequency questionnaire and telephone interviews. Blood samples were collected from 76% of participants while saliva samples were collected in CLL cases and participants refusing blood extractions. Clinical information was recorded for cases and paraffin blocks and/or fresh tumor samples are available in most collaborating hospitals. Genotyping was done through an exome array enriched with genetic markers in specific pathways. Multiple analyses are planned to assess the association of environmental, personal and genetic risk factors for each tumor and to identify pleiotropic effects. DISCUSSION: This study, conducted within the Spanish Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), is a unique initiative to evaluate etiological factors for common cancers and will promote cancer research and prevention in Spain. |
| File Format | HTM / HTML |
| ISSN | 02139111 |
| Issue Number | 4 |
| Journal | Gaceta Sanitaria |
| Volume Number | 29 |
| e-ISSN | 15781283 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-07-01 |
| Publisher Place | Spain |
| Access Restriction | Subscribed |
| Subject Keyword | Discipline Public Health |
| Content Type | Text |
| Resource Type | Article |
| Subject | Public Health, Environmental and Occupational Health |
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