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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Paulis, Ludovit Simko, Fedor Laudon, Moshe |
| Description | Country affiliation: Slovakia Author Affiliation: Paulis L ( Institute of Pathophysiology, Faculty of Medicine, Comenius University, Sasinkova 4, 81108, Bratislava, Slovakia. ludo@lfuk.sk) |
| Abstract | INTRODUCTION: Melatonin synchronizes circadian rhythms with light/dark period and it was demonstrated to correct chronodisruption. Several melatonin receptor agonists with improved pharmacokinetics or increased receptor affinity are being developed, three of them are already in clinical use. However, the actions of melatonin extend beyond chronobiology to cardiovascular and metabolic systems as well. Given the high prevalence of cardiovascular disease and their common occurrence with chronodisruption, it is of utmost importance to classify the cardiometabolic effects of the newly approved and putative melatoninergic drugs. AREAS COVERED: In the present review, the available (although very sparse) data on such effects, in particular by the approved (circadin, ramelteon, agomelatine) or clinically advanced (tasimelteon, piromelatine = Neu-P11, TIK-301) compounds are summarized. The authors have searched for an association with blood pressure, vascular reactivity, ischemia, myocardial and vascular remodeling and metabolic syndrome. EXPERT OPINION: The data suggest that cardiovascular effects of melatonin are at least partly mediated via MT(1)/MT(2) receptors and associated with its chronobiotic action. Therefore, despite the sparse direct evidence, it is believed that these effects will be shared by melatonin analogs as well. With the expected approval of novel melatoninergic compounds, it is suggested that the investigation of their cardiovascular effects should no longer be neglected. |
| File Format | HTM / HTML |
| ISSN | 13543784 |
| Issue Number | 11 |
| Volume Number | 21 |
| e-ISSN | 17447658 |
| Journal | Expert Opinion on Investigational Drugs |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2012-11-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Analytical Chemistry Discipline Pharmacology Melatonin Metabolism Receptor, Melatonin, Mt1 Agonists Receptor, Melatonin, Mt2 Animals Cardiovascular Agents Pharmacokinetics Pharmacology Therapeutic Use Cardiovascular Diseases Drug Therapy Physiopathology Circadian Rhythm Physiology Drug Design Humans Journal Article Research Support, Non-u.s. Gov't Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology Pharmacology (medical) |
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