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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lam, R. W. |
| Description | Country affiliation: Canada Author Affiliation: Lam RW ( Division of Clinical Neuroscience, Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada. r.lam@ubc.ca) |
| Abstract | Desynchronisation of normal circadian rhythms, including the sleep-wake rhythm, is common in major depressive disorder (MDD). The association between sleep disturbances and depression has long been recognised. Disturbed sleep is a diagnostic criterion for MDD, and insomnia commonly precedes the onset of symptomatic mood disorders. Disruptions of the sleep-wake cycle (sleep architecture and timing) are residual symptoms that may prevent the attainment of high-quality remission and delay recovery from MDD. Therefore, early recognition and treatment of sleep disturbances may be important for the treatment and prevention of recurrent depression. Evidence suggests that melatonergic (MT(1) and MT(2)) and the 5-HT(2C) serotonergic receptor subtypes are important modulators of circadian rhythmicity. Agomelatine is the first melatonergic antidepressant; an agonist of melatonin MT(1) and MT(2) receptors, with additional antagonist properties at the 5-HT(2C) receptors. Agomelatine combines antidepressant efficacy including quality and efficiency of sleep, with a more favourable side-effect profile than current antidepressant treatments, including neutral effects on sexual function, bodyweight and the absence of discontinuation symptoms. These positive features provide a novel approach to the treatment of depression and the attainment of high-quality remission in MDD. |
| File Format | HTM / HTML |
| ISSN | 02698811 |
| Issue Number | 7 Suppl |
| Volume Number | 22 |
| e-ISSN | 14617285 |
| Journal | Journal of Psychopharmacology |
| Language | English |
| Publisher | SAGE Publications |
| Publisher Date | 2008-09-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Acetamides Therapeutic Use Antidepressive Agents Circadian Rhythm Drug Effects Depressive Disorder, Major Drug Therapy Serotonin Antagonists Sleep Disorders, Circadian Rhythm Adverse Effects Physiopathology Psychology Humans Receptor, Melatonin, Mt1 Agonists Receptor, Melatonin, Mt2 Recurrence Serotonin 5-ht2 Receptor Antagonists Sleep Time Factors Treatment Outcome Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology Pharmacology (medical) Psychiatry and Mental Health |
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