NDLI: Altered left ventricular longitudinal diastolic function correlates with reduced systolic function immediately after anthracycline chemotherapy.

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Altered left ventricular longitudinal diastolic function correlates with reduced systolic function immediately after anthracycline chemotherapy.

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Altered left ventricular longitudinal diastolic function correlates with reduced systolic function immediately after anthracycline chemotherapy.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Stoodley, Paul W. Richards, David A. B. Boyd, Anita Hui, Rina Harnett, Paul R. Meikle, Steven R. Clarke, Jillian L. Thomas, Liza
Description	Country affiliation: Australia Author Affiliation: Stoodley PW ( Faculty of Health Science, University of Sydney, Lidcombe, NSW, Australia. pwstoodley@gmail.com)
Abstract	AIMS: The benefits from anthracycline chemotherapy are undermined by potentially life-threatening cardiotoxicity. Transthoracic echocardiography is the most commonly used method for monitoring cardiotoxicity, and centres on the measurement of left ventricular systolic function. The aim of this study was to utilize two-dimensional speckle tracking echocardiography (2DSTE) at baseline and immediately after anthracycline chemotherapy to investigate whether patients with significant changes in systolic function after anthracycline therapy would also develop alterations in diastolic parameters. METHODS AND RESULTS: Fifty-two women with histologically confirmed breast cancer were prospectively recruited. Echocardiograms were performed 1 week prior to and 1 week following chemotherapy (always before adjuvant trastuzumab or thoracic radiotherapy). Conventional Doppler, tissue velocity imaging (TVI), and 2DSTE were used to measure diastolic function. 2DSTE measurements included longitudinal diastolic strain, early (E-Sr), and late (A-Sr) myocardial strain rate. 2DSTE and left ventricular ejection fraction (LVEF) were used to measure longitudinal systolic function. Altered LV diastolic function (including E-Sr) was observed in the entire cohort after chemotherapy, with a differential reduction in participants with a post therapy LVEF <55%. Pre-chemotherapy systolic strain was found to predict reduced E-Sr post therapy (P = 0.04). Univariate predictors of E-Sr were LVEF post therapy (P = 0.049) and systolic strain post-therapy (P = 0.01). In a multivariate analysis, systolic strain after chemotherapy was the strongest independent predictor (P = 0.001). CONCLUSION: Altered LV diastolic function was observed immediately after the administration of therapeutic doses of anthracycline chemotherapy. Furthermore, our analysis indicates that the changes in diastolic function are associated with reduced systolic function.
File Format	HTM / HTML
ISSN	20472404
e-ISSN	20472412
Journal	European Heart Journal - Cardiovascular Imaging features
Issue Number	3
Volume Number	14
Language	English
Publisher	Oxford University Press
Publisher Date	2013-03-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Cardiology Anthracyclines Adverse Effects Antibodies, Monoclonal, Humanized Antineoplastic Agents Breast Neoplasms Drug Therapy Diastole Drug Effects Echocardiography, Doppler Systole Ventricular Dysfunction, Left Chemically Induced Prospective Studies Trastuzumab Physiopathology
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging Cardiology and Cardiovascular Medicine

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