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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Pokusa, Michal Prokopova, Barbora Hlavacova, Natasa Makatsori, Aikaterini Jezova, Daniela |
| Description | Country affiliation: Slovakia Author Affiliation: Pokusa M ( a Laboratory of Pharmacological Neuroendocrinology, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Vlarska 3, Bratislava 83306, Slovakia.) |
| Abstract | The aim of this study was to verify the presence of metabotropic glutamate receptor subtype 5 (mGluR5) in the adrenal gland of male rats of 2 different strains, and to test the hypothesis that treatment with mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) affects hormone release and adrenal gene expression of mGluR5 under conditions of stress. The results clearly show the gene expression of mGluR5 in the adrenal gland in both the adrenal cortex and medulla. Treatment with the glutamate release inhibitor riluzole (4 mg·(kg body mass)(-1)·day(-1) for 2 weeks) failed to modify mRNA levels of either the mGluR5 or NR1 subunit of the NMDA receptor in the adrenal glands, as measured by real-time PCR. Blockade of mGluR5 with MPEP (1 mg·kg(-1) for 4 days) increased corticosterone but not catecholamine release during restraint stress (20 min). Treatment with MPEP had no effect on mRNA levels coding for steroidogenic factors StAR and SF-1, and decreased mGluR5 gene expression in the adrenal gland. In conclusion, mGluR5 is not likely to play a significant role in stress-induced catecholamine release. Pharmacological blockade of mGluR5 has a modest influence on the hypothalamic-pituitary-adrenocortical axis, as reflected in adrenal hypertrophy and increased corticosterone concentrations. |
| File Format | HTM / HTML |
| ISSN | 00084212 |
| e-ISSN | 12057541 |
| Journal | Canadian Journal of Physiology and Pharmacology |
| Issue Number | 8 |
| Volume Number | 92 |
| Language | English |
| Publisher | Canadian Science Publishing |
| Publisher Date | 2014-08-01 |
| Publisher Place | Canada |
| Access Restriction | Open |
| Subject Keyword | Discipline Physiology Discipline Pharmacology Adrenal Cortex Drug Effects Adrenal Medulla Corticosterone Secretion Receptor, Metabotropic Glutamate 5 Antagonists & Inhibitors Stress, Psychological Metabolism Animals Gene Expression Pyridines Pharmacology Rats, Sprague-dawley Rats, Wistar Receptors, N-methyl-d-aspartate Restraint, Physical Riluzole Species Specificity Physiopathology Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology Physiology (medical) Pharmacology |
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