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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Chilakapati, Shanmuga Reddy Serasanambati, Mamatha Manikonda, Pavan Kumar Chilakapati, Damodar Reddy Watson, Ronald Ross |
| Description | Country affiliation: India Author Affiliation: Chilakapati SR ( a SugenLife Sciences Pvt. Ltd., Tirupati, Andhra Pradesh 517 505, India.) |
| Abstract | Idiopathic pulmonary fibrosis is a progressive fatal lung disease characterized by excessive collagen deposition, with no effective treatments. We investigated the efficacy of natural products with high anti-inflammatory activity, such as passion fruit peel extract (PFPE), in a mouse model of bleomycin-induced pulmonary fibrosis (PF). C57BL/6J mice were subjected to a single intratracheal instillation of bleomycin to induce PF. Daily PFPE treatment significantly reduced loss of body mass and mortality rate in mice compared with those treated with bleomycin. While bleomycin-induced PF resulted in elevated total numbers of inflammatory cells, macrophages, lymphocytes, and neutrophils in bronchoalveolar lavage fluid on both days 7 and 21, PFPE administration significantly attenuated these phenomena compared with bleomycin group. On day 7, the decreased superoxide dismutase and myeloperoxidase activities observed in the bleomycin group were significantly restored with PFPE treatment. On day 21, enhanced hydroxyproline deposition in the bleomycin group was also suppressed by PFPE administration. PFPE treatment significantly attenuated extensive inflammatory cell infiltration and accumulation of collagen in lung tissue sections of bleomycin-induced mice on days 7 and 21, respectively. Our results indicate that administration of PFPE decreased bleomycin-induced PF because of anti-inflammatory and antioxidant activities. |
| File Format | HTM / HTML |
| ISSN | 00084212 |
| e-ISSN | 12057541 |
| Journal | Canadian Journal of Physiology and Pharmacology |
| Issue Number | 8 |
| Volume Number | 92 |
| Language | English |
| Publisher | Canadian Science Publishing |
| Publisher Date | 2014-08-01 |
| Publisher Place | Canada |
| Access Restriction | Open |
| Subject Keyword | Discipline Physiology Discipline Pharmacology Anti-inflammatory Agents Therapeutic Use Antibiotics, Antineoplastic Adverse Effects Antioxidants Bleomycin Passiflora Chemistry Plant Extracts Pulmonary Fibrosis Drug Therapy Animals Pharmacology Body Weight Drug Effects Bronchoalveolar Lavage Fluid Cytology Flavonoids Hydroxyproline Metabolism Inflammation Mice, Inbred C57bl Oxidative Stress Peroxidase Phytotherapy Chemically Induced Mortality Superoxide Dismutase Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology Physiology (medical) Pharmacology |
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