NDLI: Cangene gold medal award lecture - Genomic analysis and modification of Burkholderia cepacia complex bacteriophages.

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Cangene gold medal award lecture - Genomic analysis and modification of Burkholderia cepacia complex bacteriophages.

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Cangene gold medal award lecture - Genomic analysis and modification of Burkholderia cepacia complex bacteriophages.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lynch, Karlene H. Dennis, Jonathan J.
Description	Country affiliation: Canada Author Affiliation: Lynch KH ( 6-008 Centennial Centre for Interdisciplinary Science, Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.)
Abstract	The Burkholderia cepacia complex (Bcc) is a group of 17 Gram-negative predominantly environmental bacterial species that cause potentially fatal opportunistic infections in cystic fibrosis (CF) patients. Although its prevalence in these individuals is lower than that of Staphylococcus aureus and Pseudomonas aeruginosa , the Bcc remains a serious problem in the CF community because of the pathogenicity, transmissibility, and inherent antibiotic resistance of these organisms. An alternative treatment for Bcc infections that is currently being developed is phage therapy, the clinical use of viruses that infect bacteria. To assess the suitability of individual phage isolates for therapeutic use, the complete genome sequences of a panel of Bcc-specific phages were determined and analyzed. These sequences encode a broad range of proteins with a gradient of relatedness to phage and bacterial gene products from Burkholderia and other genera. The majority of these phages were found not to encode virulence factors, and despite their predominantly temperate nature, a proof-of-principle experiment has shown that they may be modified to a lytic form. Both the genomic characterization and subsequent engineering of Bcc-specific phages are fundamental to the development of an effective phage therapy strategy for these bacteria.
File Format	HTM / HTML
ISSN	00084166
e-ISSN	14803275
Journal	Canadian Journal of Microbiology
Issue Number	3
Volume Number	58
Language	English
Publisher	Canadian Science Publishing
Publisher Date	2012-03-01
Publisher Place	Canada
Access Restriction	Open
Subject Keyword	Discipline Microbiology Bacteriophages Genetics Burkholderia Cepacia Complex Virology Genome, Viral Animals Pathogenicity Burkholderia Infections Therapy Cystic Fibrosis Complications Genomics Mice Opportunistic Infections Microbiology Virulence Factors Lectures Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Genetics Medicine Molecular Biology Immunology Microbiology Applied Microbiology and Biotechnology

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