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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Nakamoto, Tetsuya Mikuriya, Takefumi Sugahara, Kazuma Hirose, Yoshinobu Hashimoto, Tomoko Shimogori, Hiroaki Takii, Ryosuke Nakai, Akira Yamashita, Hiroshi |
| Description | Country affiliation: Japan Author Affiliation: Nakamoto T ( Department of Otolaryngology, Yamaguchi University School of Medicine, Minami-Kogushi 1-1-1, Ube, Yamaguchi 755-8505, Japan.) |
| Abstract | OBJECTIVE: Heat shock transcription factor 1 (HSF1) is a master regulator of heat shock response, and also inhibits expression of inflammatory cytokines directly or indirectly. Here, we examined effects of HSF1 activation on the expression of proinflammatory cytokines in mouse cochlea after exposure to noise. METHODS: Male CBA/N mice with normal Preyer's reflex were exposed to intense noise for 3h. Three hours after noise exposure, bilateral cochleae were removed and expression of major inflammatory cytokines was examined. RESULTS: We found that interleukin-6 (IL-6) and interleukin-1ß (IL-1ß) expression increased significantly after noise exposure, and the expression was suppressed significantly in mice administered with geranylgeranylacetone (GGA), which activates HSF1. Seven days after noise exposure, thresholds for auditory brainstem response were elevated, and GGA administration significantly suppressed this elevation. CONCLUSION: These results suggest that HSF1-mediated suppression of proinflammatory cytokines in the cochlea by GGA administration could be an important means of inner ear protection. |
| File Format | HTM / HTML |
| ISSN | 03858146 |
| Issue Number | 3 |
| Volume Number | 39 |
| e-ISSN | 18791476 |
| Journal | Auris Nasus Larynx |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-06-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Otolaryngology Cochlea Drug Effects Cytokines Dna-binding Proteins Metabolism Diterpenes Pharmacology Hearing Loss, Noise-induced Inflammation Transcription Factors Animals Auditory Threshold Evoked Potentials, Auditory, Brain Stem Interleukin-1beta Interleukin-6 Male Mice Mice, Inbred Cba Noise Real-time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Otorhinolaryngology Surgery |
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